PubAngioGen: a database and knowledge for angiogenesis and related diseases

Area of Science:

• Biomedical Science
• Molecular Biology
• Genetics

Background:

• Angiogenesis, the formation of new blood vessels, is crucial in diseases like cancer, cardiovascular conditions, and diabetes.
• Numerous angiogenic factors have been identified as therapeutic targets, but data remains fragmented.
• Existing research lacks systematic summarization, hindering comprehensive understanding and drug development.

Purpose of the Study:

• To create a centralized resource for angiogenesis research by integrating scattered information.
• To develop a database and online application, PubAngioGen, for exploring angiogenesis-disease connections.
• To facilitate research in anti-angiogenic and pro-angiogenic drug development.

Main Methods:

• Manual text-mining of published scientific literature.
• Construction of the PubAngioGen database and online application.
• Integration with external databases such as STRING, DrugBank, and OMIM.

Main Results:

• PubAngioGen provides a network for exploring angiogenesis-disease relationships at multiple levels.
• The database includes protein-protein interactions, drug-target information, disease-gene associations, and signaling pathways.
• Data covers various cell types and animal models, extracted through text-mining.

Conclusions:

• PubAngioGen offers a comprehensive, integrated platform for angiogenesis research.
• The database facilitates the understanding of molecular mechanisms underlying angiogenesis in disease.
• PubAngioGen supports the development of novel therapeutic strategies for angiogenesis-related diseases.