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Suppression of human monocyte interleukin 1 production by the plant alkaloid tetrandrine
1Immunobiology Laboratory Department of Child Health, University of Queensland, Mater Children's Hospital, South Brisbane, Australia.
Clinical and Experimental Immunology
|January 1, 1989
Abstract:
The bisbenzylisoquinoline alkaloid, tetrandrine, was shown to affect some important human monocyte functions. The drug caused significant inhibition of random movement, chemotaxis, superoxide anion generation and interleukin 1 (IL-1) production. By contrast, degranulation and hexose-monophosphate shunt activity were unaffected. Tetrandrine may be of value in the treatment of chronic inflammatory diseases where IL-1 has a major role as an inflammatory mediator.