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Viruses in acute gastroenteritis in children in Pune, India

P B Singh1, M A Sreenivasan, K M Pavri

  • 1National Institute of Virology, Pune, India.

Epidemiology and Infection
|April 1, 1989
PubMed

Insights

Rotavirus was a significant cause of diarrhea in hospitalized Indian children under five. An inverse relationship was observed between rotavirus and coronavirus-like particles (CVLP) prevalence.

Area of Science:

  • Virology
  • Pediatric Gastroenterology
  • Infectious Diseases

Background:

  • Diarrhea is a major cause of childhood morbidity and mortality globally.
  • Viral pathogens are frequently implicated in pediatric gastroenteritis.

Purpose of the Study:

  • To investigate the role of viruses in childhood diarrhea in hospitalized Indian children.
  • To identify specific viral agents and their prevalence in diarrheal cases.

Main Methods:

  • A 2-year study (1981-1982) involving 426 children (213 diarrheal, 213 controls) in Pune, India.
  • Stool sample analysis using electron microscopy and ELISA for viral detection.
  • Identification of rotavirus, coronavirus-like particles (CVLP), adenovirus, astrovirus, calicivirus, and small round virus-like particles (SRV).

Main Results:

  • Rotavirus was detected in 28.6% of diarrheal patients versus 1.4% of controls, predominantly in children under 5 years.
  • Coronavirus-like particles (CVLP) were more prevalent in controls (23.0%) than in diarrheal cases (8.9%), with seasonal variations.
  • An inverse relationship was noted between CVLP and rotavirus detection.

Conclusions:

  • Rotavirus is a key viral agent causing diarrhea in young hospitalized children in this Indian population.
  • The findings suggest distinct epidemiological patterns for different viral agents, including an inverse association between rotavirus and CVLP.

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