Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Pharmaceutical Alternatives: Polymorphic Form-Related and Particle Size-Related Therapeutic Nonequivalence01:27

Pharmaceutical Alternatives: Polymorphic Form-Related and Particle Size-Related Therapeutic Nonequivalence

227
Changes in polymorphic forms can significantly influence the bioavailability of poorly soluble drugs. Although the FDA defines pharmaceutical equivalence based on having the same active ingredient, dosage form, and route of administration, it does not automatically disqualify products with different polymorphic forms. This means two products with different polymorphs can still be deemed pharmaceutically equivalent. However, polymorphic differences can affect properties like wettability,...
227
Factors Affecting Dissolution: Polymorphism, Amorphism and Pseudopolymorphism01:21

Factors Affecting Dissolution: Polymorphism, Amorphism and Pseudopolymorphism

897
Polymorphism refers to the existence of a drug substance in multiple crystalline forms, known as polymorphs. Recently, this term has been expanded to include solvates (forms containing a solvent), amorphous forms (non-crystalline forms), and desolvated solvates (forms from which the solvent has been removed).
Some polymorphic crystals possess lower aqueous solubility than their amorphous counterparts, leading to incomplete absorption. For instance, the oral suspension of Chloramphenicol, which...
897
Phase Changes01:19

Phase Changes

5.7K
Phase transitions play an important theoretical and practical role in the study of heat flow. In melting or fusion, a solid turns into a liquid; the opposite process is freezing. In evaporation, a liquid turns into a gas; the opposite process is condensation.
A substance melts or freezes at a temperature called its melting point and boils or condenses at its boiling point. These temperatures depend on pressure. High pressure favors the denser form of the substance, so typically, high pressure...
5.7K
Phase Diagram01:19

Phase Diagram

7.3K
The phase of a given substance depends on the pressure and temperature. Thus, plots of pressure versus temperature showing the phase in each region provide considerable insights into the thermal properties of substances. Such plots are known as phase diagrams. For instance, in the phase diagram for water (Figure 1), the solid curve boundaries between the phases indicate phase transitions (i.e., temperatures and pressures at which the phases coexist).
7.3K
Phase Diagram01:24

Phase Diagram

165
A phase diagram is a graphical representation of the physical states of a substance under different conditions of temperature and pressure. It shows the boundaries between solid, liquid, and gas phases and the conditions at which these phases coexist in equilibrium. An area in a phase diagram represents a single phase, whereas lines or phase boundaries represent the equilibrium between two phases.In the phase diagram of water, the boundary line between the solid and liquid states illustrates...
165
Phase Transitions02:31

Phase Transitions

24.1K
Whether solid, liquid, or gas, a substance's state depends on the order and arrangement of its particles (atoms, molecules, or ions). Particles in the solid pack closely together, generally in a pattern. The particles vibrate about their fixed positions but do not move or squeeze past their neighbors. In liquids, although the particles are closely spaced, they are randomly arranged. The position of the particles are not fixed—that is, they are free to move past their neighbors to...
24.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Pressure induced ferromagnetic to antiferromagnetic phase transition in transition metal chalcogenide Cr<sub>3</sub>Te<sub>4</sub>.

Journal of physics. Condensed matter : an Institute of Physics journal·2026
Same author

Depth-dependent anisotropy in the Earth's inner core linked to chemical stratification.

Nature communications·2025
Same author

Multiple freezing-melting pathways of high-density ice through ice XXI phase at room temperature.

Nature materials·2025
Same author

Role of restraints on hydrogen atoms in Hirshfeld atom refinement: the case of tri-aspartic acid trihydrate.

Acta crystallographica Section B, Structural science, crystal engineering and materials·2025
Same author

Crystal Structure of Carbonic Acid (H<sub>2</sub>CO<sub>3</sub>) at Elevated Pressures from Single-Crystal Diffraction.

Chemistry (Weinheim an der Bergstrasse, Germany)·2025
Same author

Physical Stability and Molecular Mobility of Resveratrol in a Polyvinylpyrrolidone Matrix.

Molecules (Basel, Switzerland)·2025

Related Experiment Video

Updated: Apr 21, 2026

Synthesis and Characterization of Multi-Modal Phase-Change Porphyrin Droplets
07:59

Synthesis and Characterization of Multi-Modal Phase-Change Porphyrin Droplets

Published on: October 15, 2021

4.1K

The polymorphic phase transformations in the chlorpropamide under pressure.

Sergey E Kichanov1, Denis P Kozlenko, Jan Wąsicki

  • 1Frank Laboratory of Neutron Physics, JINR, Dubna, 141980, Moscow Region, Russia.

Journal of Pharmaceutical Sciences
|November 14, 2014
PubMed
Summary

Chlorpropamide undergoes significant structural changes under high pressure, including two polymorphic phase transitions and a transformation to an amorphous phase. These findings reveal its pressure-dependent crystal behavior.

Keywords:
Raman spectroscopyX-ray powder diffractometryamorphouscrystal structurepolymorphism

More Related Videos

High-Contrast and Fast Photorheological Switching of a Twist-Bend Nematic Liquid Crystal
06:24

High-Contrast and Fast Photorheological Switching of a Twist-Bend Nematic Liquid Crystal

Published on: October 31, 2019

7.0K
A Package of Established Analytical Tools to Investigate the Solid-State Alteration of Lipid-Based Excipients
11:27

A Package of Established Analytical Tools to Investigate the Solid-State Alteration of Lipid-Based Excipients

Published on: August 9, 2022

2.7K

Related Experiment Videos

Last Updated: Apr 21, 2026

Synthesis and Characterization of Multi-Modal Phase-Change Porphyrin Droplets
07:59

Synthesis and Characterization of Multi-Modal Phase-Change Porphyrin Droplets

Published on: October 15, 2021

4.1K
High-Contrast and Fast Photorheological Switching of a Twist-Bend Nematic Liquid Crystal
06:24

High-Contrast and Fast Photorheological Switching of a Twist-Bend Nematic Liquid Crystal

Published on: October 31, 2019

7.0K
A Package of Established Analytical Tools to Investigate the Solid-State Alteration of Lipid-Based Excipients
11:27

A Package of Established Analytical Tools to Investigate the Solid-State Alteration of Lipid-Based Excipients

Published on: August 9, 2022

2.7K

Area of Science:

  • Solid-state chemistry
  • Materials science
  • Crystallography

Background:

  • Chlorpropamide is an antidiabetic medication.
  • Understanding its high-pressure behavior is crucial for material science applications.

Purpose of the Study:

  • To investigate the crystal structure and vibrational spectra of chlorpropamide under varying pressures.
  • To identify pressure-induced phase transitions and structural modifications.

Main Methods:

  • X-ray diffraction was used to study crystal structure up to 24.6 GPa.
  • Raman spectroscopy was employed to analyze vibrational spectra up to 4.4 GPa.

Main Results:

  • Two polymorphic phase transitions were observed: orthorhombic to monoclinic (form-AI) at ~1.2 GPa, and to another monoclinic (form-AII) at ~3.0 GPa.
  • A transformation to an amorphous phase occurred above 9.6 GPa.
  • Lattice parameters, unit cell volumes, and vibration modes were determined for each phase.

Conclusions:

  • Chlorpropamide exhibits distinct polymorphic forms and an amorphous phase under high pressure.
  • Pressure significantly alters the structural and vibrational properties of chlorpropamide.