High APRIL expression correlates with unfavourable survival of gastrointestinal stromal tumour

A proliferation inducing ligand (APRIL) is a member of the tumour necrosis factor superfamily. High APRIL expression has been found to correlate with tumour development, suggesting that APRIL participates in oncogenesis. However, little is known about APRIL expression in gastrointestinal stromal tumours (GISTs) or the relationship between APRIL expression and the clinical characteristics of GIST. Therefore, we assessed the expression of APRIL immunohistochemically using a tissue microarray from 178 patients with GIST and evaluated the relationship between APRIL expression and patient prognosis. Strong APRIL expression was observed in 42.7% of GISTs, with APRIL expression significantly associated with tumour diameter, gross classification and tumour grade (p < 0.05 each). Kaplan-Meier analysis suggested that low APRIL expression and tumour size <5 cm were associated with longer overall survival. These findings indicate that APRIL expression is correlated with malignant GIST phenotypes and it may serve as an unfavourable prognostic marker in patients with GIST.