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Physical function as a prognostic biomarker among cancer survivors
J C Brown1, M O Harhay1, M N Harhay2
1Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, 423 Guardian Drive, 8th Floor, Blockley Hall, Philadelphia, PA 19104, USA.
Background:
We tested the hypothesis that objectively measured physical function predicts mortality among cancer survivors.
Methods:
We assessed objectively measured physical function including the short physical performance battery (SPPB) and fast walk speed in older adult cancer survivors.
Results:
Among 413 cancer survivors, 315 (76%) died during a median follow-up of 11.0 years. In multivariable-adjusted analyses, each 1-unit increase in the SPPB score and 0.1 m s(-1) increase in fast walk speed predicted a 12% reduction in mortality (hazard ratio (HR): 0.88 (95% confidence interval (CI): 0.82-0.94); P<0.001, and HR: 0.88 (95% CI: 0.82-0.96); P=0.003, respectively).
Conclusions:
Objectively measured physical function may predict mortality among cancer survivors.
