Related Experiment Video
Updated: Apr 21, 2026

Assessment of the Efficacy of An Osteopathic Treatment in Infants with Biomechanical Impairments to Suckling
Published on: February 5, 2019
Medical intervention in parent-reported infant gastro-oesophageal reflux: A population-based study
Sun Hua1,2, Rachel L Peters1,3, Katrina J Allen1,4,5,3
1Murdoch Childrens Research Institute, Royal Children's Hospital, Melbourne, Victoria, Australia.
Insights
Approximately 14% of infants seek medical advice for gastro-oesophageal reflux (GOR) in their first year. Anti-reflux medication use is high, even for uncomplicated GOR, despite lacking evidence of effectiveness.
Area of Science:
- Pediatrics
- Gastroenterology
- Public Health
Background:
- Gastro-oesophageal reflux (GOR) is common in infants.
- Understanding health-seeking behaviors and medical interventions for GOR is crucial for appropriate infant care.
Purpose of the Study:
- To determine the incidence of gastro-oesophageal reflux (GOR) in infants within the first year of life.
- To investigate health-seeking behaviors and medical interventions for infants experiencing GOR symptoms.
Main Methods:
- The study utilized data from the longitudinal, population-based HealthNuts study.
- Infant GOR symptoms, food allergy, and treatments were assessed via parental questionnaires at 12 months.
- Logistic regression modeled factors associated with seeking healthcare for infant GOR.
Main Results:
- Gastro-oesophageal reflux (GOR) was reported in 23% of 4674 infants, with 64% consulting a medical practitioner.
- Factors influencing medical consultation included prematurity and family history of atopy.
- Anti-reflux medication was used by 8% of infants, and 6% changed formula, with parental perception of infant distress and symptom duration being key factors for seeking treatment.
Conclusions:
- Around 14% of infants receive medical advice for gastro-oesophageal reflux (GOR) symptoms annually.
- The widespread use of anti-reflux medication for uncomplicated GOR persists, despite limited evidence supporting its efficacy.
- Further research is needed to guide appropriate management strategies for infant GOR.
Aim:
To report the cumulative incidence, health-seeking behaviour and medical intervention of infants with gastro-oesophageal reflux (GOR) in the first year of life.
Methods:
The HealthNuts study is a longitudinal, population-based study. At 12 months of age, infants underwent skin prick testing to food allergens, including cows milk. Parents completed a questionnaire on GOR symptoms, food allergy and treatments. Factors associated with seeking health care for infants with GOR were modelled using logistic regression.
Results:
Of 4674 infants, parents reported GOR in 1054 (23%; 95% confidence interval (CI) 21.4-23.8). Parents consulted a medical practitioner in 662 (64%) cases. Symptoms commenced in the first month in 411 (48%) and resolved within 6 months in 703 (75%) infants. Factors associated with doctor consultation for GOR were prematurity (adjusted odds ratio (aOR) 1.94; 95% CI 1.43-2.63) and family history of atopy (aOR 1.64; 95% CI 1.1-2.43). Eight per cent of infants (371/4674; 95% CI 7.2-8.7) received anti-reflux medication and 6% (296/4674; 95% CI 5.7-7.1) changed formula. Parents were more likely to seek treatment if they perceived their infant to be unsettled (aOR 2.55; 95% CI 1.26-5.17) and if the duration of GOR was prolonged (aOR 3.36 for symptoms >6 months; 95% CI 1.83-6.17).
Conclusions:
In the first year of life, approximately 14% of the population seek medical advice for GOR symptoms. The use of anti-reflux medication in the general community remains high, despite the absence of evidence that it is appropriate or effective for uncomplicated GOR.
Related Concept Videos
Gastroesophageal Reflux Disease II: Clinical Features and Management
Clinical Manifestations
GERD presents itself in a multitude of ways, with symptoms varying from person to person. The hallmark symptoms are...
Gastroesophageal Reflux Disease
Enteral Nutrition II: Nasointestinal and Gastrostomy Feeding
Nasointestinal Feeding
Nasointestinal feeding involves placing a tube...
Esophageal Strictures-II: Clinical Features and Management
Healthcare providers should gather a comprehensive medical history and conduct a physical examination for diagnosis. If esophageal stricture is...
Barrett Esophagus-II: Clinical Manifestations and Management
To diagnose Barrett's esophagus, healthcare providers often recommend an endoscopy for those showing symptoms of acid reflux. The procedure...
Peptic Ulcer Disease V: Surgical Management and Nursing Care
Surgical Interventions for Peptic Ulcer Disease

