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Local Field Fluorescence Microscopy: Imaging Cellular Signals in Intact Hearts
Published on: March 8, 2017
Cardiac-induced localized thoracic motion detected by a fiber optic sensing scheme
Thomas Allsop1, Glynn Lloyd2, Ranjeet S Bhamber3
1Aston University, Aston Institute of Photonic Technologies, School of Engineering and Applied Science, Aston Triangle, Birmingham B4 7ET, United Kingdom.
Insights
A novel fiber optic sensor system captures detailed heart motion, enabling real-time 3-D visualization. This low-cost, portable technology offers a new way to monitor cardiovascular health and detect heart conditions.
Area of Science:
- Biomedical Engineering
- Cardiovascular Research
- Sensor Technology
Background:
- Cardiovascular diseases are a leading cause of global mortality, necessitating advanced diagnostic tools.
- Current methods for assessing cardiovascular health can be expensive or impractical for widespread use.
Purpose of the Study:
- To develop a novel, cost-effective, and portable system for real-time 3-D visualization of cardiac mechanical motion.
- To capture seismocardiographic signals across a broad frequency range, including ballistocardiography and heart sounds.
Main Methods:
- Utilized a system of fiber optic long period gratings as curvature sensors to detect seismocardiographic signals up to 54 Hz.
- Employed a bespoke 3-D shape reconstruction algorithm with data from an array of 3-4 sensors placed on the thorax near the heart's apex.
- Demonstrated visualization of real-time, three-dimensional (3-D) mechanical heart motion.
Main Results:
- Successfully obtained seismocardiographic signals covering both ballistocardiography and audible heart sound frequencies.
- Visualized complex heart wall motion in the apex region using the developed sensing and reconstruction technique.
- The system proved to be low-cost, portable, and easy to operate.
Conclusions:
- The developed fiber optic sensing system provides a novel, low-cost method for real-time 3-D cardiac motion visualization.
- This technology has significant potential for ambulatory cardiovascular health monitoring and diagnostics.
- The system's ability to capture a wide range of cardiac mechanical signals offers a comprehensive approach to heart assessment.
Abstract:
The cardiovascular health of the human population is a major concern for medical clinicians, with cardiovascular diseases responsible for 48% of all deaths worldwide, according to the World Health Organization. The development of new diagnostic tools that are practicable and economical to scrutinize the cardiovascular health of humans is a major driver for clinicians. We offer a new technique to obtain seismocardiographic signals up to 54 Hz covering both ballistocardiography (below 20 Hz) and audible heart sounds (20 Hz upward), using a system based on curvature sensors formed from fiber optic long period gratings. This system can visualize the real-time three-dimensional (3-D) mechanical motion of the heart by using the data from the sensing array in conjunction with a bespoke 3-D shape reconstruction algorithm. Visualization is demonstrated by adhering three to four sensors on the outside of the thorax and in close proximity to the apex of the heart; the sensing scheme revealed a complex motion of the heart wall next to the apex region of the heart. The detection scheme is low-cost, portable, easily operated and has the potential for ambulatory applications.
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