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Binding of iron(II) ions to the pentose sugar 2-deoxyribose
O I Aruoma1, S S Chaudhary, M Grootveld
1Department of Biochemistry, University of London King's College, U.K.
Journal of Inorganic Biochemistry
|February 1, 1989
Abstract:
Iron(II) ions are able to form a weak complex (apparent equilibrium constant about 10(2) at pH 7.4 and 25 degrees C) with 2-deoxyribose over a range of pH values, including pH 7. Evidence for this complex formation has been obtained by spectrophotometric experiments and by studies of Fe(II) oxidation. Iron(II) ions bound to deoxyribose seem to react with H2O2, in a site-specific reaction, to form hydroxyl radicals (.OH) that immediately damage the deoxyribose molecule.