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Metal-organic framework based highly selective fluorescence turn-on probe for hydrogen sulphide
Sanjog S Nagarkar1, Tanmoy Saha1, Aamod V Desai1
1Indian Institute of Science Education &Research (IISER), Pune Dr. Homi Bhabha Road, Pashan, Pune-411008 (India).
Scientific Reports
|November 15, 2014
Summary
Researchers developed a novel azide-functionalized metal-organic framework (MOF) for detecting hydrogen sulfide (H2S). This selective fluorescent probe offers a fast, turn-on response, enabling H2S monitoring in biological systems.
Area of Science:
- Biochemistry
- Materials Science
- Chemical Biology
Background:
- Hydrogen sulfide (H2S) is crucial in human physiology and pathology.
- Understanding H2S production pathways and mechanisms is challenging due to its volatile and reactive nature.
Purpose of the Study:
- To develop a selective and sensitive probe for detecting H2S.
- To investigate the potential of metal-organic frameworks (MOFs) for H2S detection in biological systems.
Main Methods:
- Synthesis of an azide-functionalized metal-organic framework (MOF).
- Evaluation of the MOF's fluorescence response to H2S in the presence of other biomolecules.
- Assessment of cytotoxicity and detection of H2S in live cells.
Main Results:
- The azide-functionalized MOF demonstrated a selective turn-on fluorescent response to H2S.
- The probe exhibited a fast response and high selectivity, even with interfering biomolecules.
- The MOF showed low cytotoxicity and enabled H2S detection in live cells.
Conclusions:
- This study presents the first MOF with a fast, highly selective fluorescence turn-on response for H2S detection under physiological conditions.
- The developed MOF probe holds significant potential for monitoring H2S chemistry in biological environments.
