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Tear function in patients with chronic renal failure undergoing hemodialysis
Serdar Aktaş1, Hacı Murat Sağdık, Hatice Aktaş
1Department of Ophthalmology, Dumlupinar University School of Medicine , Kutahya , Turkey .
Renal Failure
|November 15, 2014
Summary
Patients with chronic renal failure (CRF) experience more dry eye symptoms and reduced tear film quality. An eye exam is recommended for early detection and management of ocular surface disease in CRF patients.
Area of Science:
- Ophthalmology
- Nephrology
- Dry Eye Disease
Background:
- Chronic renal failure (CRF) affects multiple organ systems.
- Ocular surface complications are increasingly recognized in CRF patients.
Purpose of the Study:
- To investigate dry eye symptoms and tear film abnormalities in non-diabetic CRF patients undergoing hemodialysis.
- To correlate clinical findings with patient-reported symptoms.
Main Methods:
- A cohort of 35 non-diabetic CRF patients on hemodialysis and 31 healthy controls were recruited.
- Ocular Surface Disease Index (OSDI) questionnaire assessed dry eye symptoms.
- Schirmer and Tear Break-Up Time (TBUT) tests evaluated tear film function.
Main Results:
- CRF patients reported significantly higher OSDI scores, indicating more severe dry eye symptoms (p<0.01).
- Tear Break-Up Time (TBUT) was significantly reduced in CRF patients (p=0.01).
- Schirmer test results showed a trend towards lower tear production in CRF patients, but without statistical significance (p=0.20).
Conclusions:
- Non-diabetic patients with chronic renal failure exhibit significant dry eye symptoms and tear film instability.
- Ophthalmic examinations are crucial for CRF patients to screen for and manage dry eye disease.
- Early detection of ocular surface disease can prevent further complications.
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