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Related Experiment Videos

Association between renal function and cognitive ability domains in the Einstein aging study: a cross-sectional

Andrea R Zammit1, Mindy J Katz2, Jennifer Y Lai3

  • 1Saul B. Korey Department of Neurology, the Einstein Aging Study, richard.lipton@einstein.yu.edu.

The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
|November 15, 2014
PubMed
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Reduced kidney function, indicated by low estimated glomerular filtration rate (eGFR), is linked to poorer executive function in older adults. Early assessment for cognitive impairment is recommended for individuals with diminished renal function.

Area of Science:

  • Gerontology
  • Nephrology
  • Neuropsychology

Background:

  • Limited research exists on the link between kidney function and cognitive domains in community-dwelling older adults.
  • This study investigates the association between renal function and cognitive performance using comprehensive neurocognitive assessments.

Purpose of the Study:

  • To examine the relationship between estimated glomerular filtration rate (eGFR) and specific cognitive functions in older adults.
  • To identify cognitive domains affected by reduced kidney function.

Main Methods:

  • Utilized data from 649 participants (age 70+) in the Einstein Aging Study.
  • Calculated eGFR and categorized participants into low (<45), medium (45-59), and high (≥60) groups.
  • Applied principal component analysis to 13 neurocognitive tests, identifying global, episodic memory, and frontal-executive components.
Keywords:
CognitionExecutive function.Renal function

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Main Results:

  • The frontal-executive cognitive domain showed a significant association with poor performance in the low eGFR group (p <.001).
  • Specifically, performance on the Trail Making Test Part B and Digit Symbol Substitution test was lower in individuals with low eGFR.
  • No significant associations were found between eGFR and other cognitive domains like global cognition or episodic memory.

Conclusions:

  • Low eGFR is associated with impaired executive function in older adults.
  • Cognitive impairment screening is advised for individuals with reduced kidney function.
  • Potential underlying mechanisms linking renal function and executive function are discussed.