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Updated: Apr 21, 2026
A Murine Model of Dengue Virus-induced Acute Viral Encephalitis-like Disease
Published on: April 28, 2019
Perinatal transmission of dengue: a case report
Vindika Prasad Sinhabahu, Rajeev Sathananthan, Gathsaurie Neelika Malavige1
1Centre for Dengue Research, Faculty of Medical Sciences, University of Sri Jayawardanapura, Nugegoda, Sri Lanka. gathsaurie.malavige@ndm.ox.ac.uk.
Background:
Dengue in pregnancy is associated with many maternal and foetal outcomes including perinatal transmission of dengue infection.
Case Presentation:
A baby was born by emergency caesarean section due to foetal distress and meconium stained liquor, to a 27-year old primi-gravidae, Sinhalese female, who was febrile during and 2 days prior to labour. The baby had evidence of respiratory distress due to meconium aspiration and was cared for in the special care baby unit for 3 days. On the 4th day he developed fever and serial blood counts showed a gradual rise in the haematocrit (>20% of baseline value) and lowering of platelet counts. The baby was treated for sepsis and as Sri Lanka was experiencing a massive dengue epidemic was also tested for dengue. His dengue NS1 antigen test was strongly positive and the dengue IgM antibodies weakly positive on day 3 of illness. The mother was positive for both dengue IgM and IgG antibodies.
Conclusion:
Although rare, vertical transmission of the dengue virus has been reported and the baby most likely developed dengue due to perinatal transmission of dengue.
