Related Experiment Video
Updated: Apr 21, 2026

An Emerging Target Paradigm to Evoke Fast Visuomotor Responses on Human Upper Limb Muscles
Published on: August 25, 2020
Complement--tapping into new sites and effector systems
Martin Kolev1, Gaelle Le Friec1, Claudia Kemper2
11] Division of Transplant Immunology and Mucosal Biology, MRC Centre for Transplantation, King's College London, Faculty of Life Sciences and Medicine, Guy's Hospital, London SE1 9RT, UK. [2].
Abstract:
Complement is traditionally known to be a system of serum proteins that provide protection against pathogens through direct cell lysis and the mobilization of innate and adaptive immunity. However, recent work indicates that the complement system has additional physiological roles beyond those in host defence. In this Opinion article, we describe the new modes and locations of complement activation that enable it to interact with other cell effector systems, such as growth factor receptors, inflammasomes and metabolic pathways. We propose that the location of complement activation dictates its function.
Related Concept Videos
Transducer Mechanism: Enzyme-Linked Receptors
Major types that are helpful drug targets include:
Complement System
Cell-matrix's Response to Mechanical Forces
Anchoring junctions mechanically attach a cell to the...
Somatosensation
Intracellular Signaling Affects Focal Adhesions
Some...
Tension Response at Adherens Junctions
α-Catenin as a Mechanosensory Protein
The α-catenin of adherens junctions is an allosteric protein with three VH (vinculin...

