Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

The Tumor Microenvironment02:17

The Tumor Microenvironment

8.3K
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
8.3K
Chronic Inflammation: Introduction01:12

Chronic Inflammation: Introduction

5
Chronic inflammation is a prolonged, dysregulated immune response that persists for weeks to years when the inciting stimulus is difficult to eradicate or when self‑antigens drive ongoing reactivity. Morphologically, it is defined by mononuclear cell infiltration, progressive tissue destruction, and concurrent attempts at healing via angiogenesis and fibrosis. Compared with acute inflammation, edema is less prominent while cellular infiltration predominates; triggers include persistent...
5
Inflammation01:38

Inflammation

66.1K
Overview
66.1K
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

9.2K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
9.2K
Inflammation: Introduction01:28

Inflammation: Introduction

5
Inflammation is a fundamental, protective biological response of vascularized tissues to cellular injury, infection, or harmful stimuli. Its primary function is to eliminate the initial cause of injury, clear necrotic cells and damaged tissue, and initiate the necessary repair processes.Cardinal SignsAcute inflammation presents with classic signs. Redness results from vasodilation and increased blood flow. Heat is due to increased metabolism and circulation. Swelling results from the...
5
The JAK-STAT Signaling Pathway01:20

The JAK-STAT Signaling Pathway

14.3K
Several cytokine receptors have tightly bound Janus kinase or JAK proteins attached at their cytosolic tail. Small signaling molecules such as cytokines, growth hormones, or prolactins bind to the cytokine receptors and initiate their dimerization. The dimerization brings the cytosolic JAKs together that trans-phosphorylate and activates each other. The activated JAKs now phosphorylate cytosolic tails of the cytokine receptors, which serve as binding sites for adaptor proteins such as  SH2...
14.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Suitability of intravascular imaging for assessment of cerebrovascular diseases.

Neuroradiology·2019
Same author

[Papillary tumors - therapeutic concepts].

Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen·2015
Same author

BRCA1 promoter methylation is a marker of better response to platinum-taxane-based therapy in sporadic epithelial ovarian cancer.

Journal of cancer research and clinical oncology·2014
Same author

BRCA1 promoter methylation is a marker of better response to anthracycline-based therapy in sporadic TNBC.

Breast cancer research and treatment·2013
Same author

[Pathowiki. A free expert database for pathology].

Der Pathologe·2012
Same author

Interlamellar cohesion after corneal crosslinking using riboflavin and ultraviolet A light.

The British journal of ophthalmology·2011

Related Experiment Video

Updated: Apr 21, 2026

Three-Dimensional Bone Extracellular Matrix Model for Osteosarcoma
08:07

Three-Dimensional Bone Extracellular Matrix Model for Osteosarcoma

Published on: April 12, 2019

7.8K

[Inflammation as molecular target in chondrosarcoma].

T Kalinski1

  • 1Institut für Pathologie, Otto-von-Guericke-Universität, Leipziger Str. 44, 39120, Magdeburg, Deutschland, kalinski@med.ovgu.de.

Der Pathologe
|November 15, 2014
PubMed
Summary

Inflammation promotes chondrosarcoma growth via tumor-associated macrophages (TAM) and Interleukin-1 (IL-1). Blocking IL-1 may inhibit tumor progression and angiogenesis, offering a potential therapy target.

Area of Science:

  • Oncology
  • Immunology
  • Molecular Biology

Context:

  • Inflammation plays a key role in malignant tumor development and progression.
  • In chondrosarcoma, tumor-associated macrophages (TAM) can promote tumor growth.
  • Interleukin-1 (IL-1), produced by TAMs, influences chondrosarcoma cells.

Purpose:

  • To investigate the role of IL-1 in chondrosarcoma progression.
  • To explore the potential of IL-1 blockade as a therapeutic strategy for chondrosarcoma.

Summary:

  • IL-1, an inflammatory cytokine from TAMs, induces NF-κB-regulated genes like vascular endothelial growth factor A (VEGF-A) in chondrosarcoma cells.
  • This IL-1-induced VEGF-A expression promotes angiogenesis.
  • IL-1-induced VEGF-A expression and angiogenesis can be inhibited by IL-1 antagonists or substances like curcumin.

More Related Videos

Creation of a Knee Joint-on-a-Chip for Modeling Joint Diseases and Testing Drugs
12:44

Creation of a Knee Joint-on-a-Chip for Modeling Joint Diseases and Testing Drugs

Published on: January 27, 2023

4.7K
Cytotoxic Efficacy of Photodynamic Therapy in Osteosarcoma Cells In Vitro
08:04

Cytotoxic Efficacy of Photodynamic Therapy in Osteosarcoma Cells In Vitro

Published on: March 18, 2014

13.4K

Related Experiment Videos

Last Updated: Apr 21, 2026

Three-Dimensional Bone Extracellular Matrix Model for Osteosarcoma
08:07

Three-Dimensional Bone Extracellular Matrix Model for Osteosarcoma

Published on: April 12, 2019

7.8K
Creation of a Knee Joint-on-a-Chip for Modeling Joint Diseases and Testing Drugs
12:44

Creation of a Knee Joint-on-a-Chip for Modeling Joint Diseases and Testing Drugs

Published on: January 27, 2023

4.7K
Cytotoxic Efficacy of Photodynamic Therapy in Osteosarcoma Cells In Vitro
08:04

Cytotoxic Efficacy of Photodynamic Therapy in Osteosarcoma Cells In Vitro

Published on: March 18, 2014

13.4K

Impact:

  • IL-1 blockade represents a promising therapeutic target for chondrosarcoma.
  • Targeting the IL-1 pathway could offer a novel treatment approach for chondrosarcoma patients.
  • Understanding the inflammatory mechanisms in chondrosarcoma can lead to improved therapeutic strategies.