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Development, Characterization, and Evaluation of CAGE-based Ionic Liquid Systems for Transdermal Delivery
Published on: September 26, 2025
Polymeric Aggregates in Ionic Liquids: The Green Future of the Delivery Systems
Guido Angelini, Carla Gasbarri1
1Department of Pharmacy, University "G. d'Annunzio" of Chieti-Pescara, via dei Vestini, 66100 Chieti, Italy. c.gasbarri@unich.it.
Abstract:
The self-assembly of a series of triblock co polymers Pluronics (P85, P105 and L121) has been investigated in some ionic liquids (BMIMBF4, BMIMPF6 and BMIMTf2N) by using Near-Infrared spectroscopy. The formation of supramolecular s tructures has been confirmed by optical microscopy. The solvation degree and the aggregation behaviour of P85, P105 and L121 depend on the interactions between the imidazolium ring of the ionic liquid and the hydrophilic moiety of the copolymer. Fluorescent vesicles can be observed after the incorporation of Nile Red into the polymeric bilayer of L121 or by linking fluorescein isothiocyanate to the copolymer structure.
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Factors Affecting Dissolution: Polymorphism, Amorphism and Pseudopolymorphism
Some polymorphic crystals possess lower aqueous solubility than their amorphous counterparts, leading to incomplete absorption. For instance, the oral suspension of Chloramphenicol, which...

