Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Social Traps01:41

Social Traps

Social traps are negative situations where people get caught in a direction or relationship that later proves to be unpleasant, with no easy way to back out of or avoid. The concept was orignally introduced by John Platt who applied psychology to Garrett Hardin's "Tragedy of the Commons", where in New England herd owners could let their cattle graze in the common ground. This situation seems like a good idea, but an individual could have an advantage. If they owned more cows, the larger...
Deindividuation00:57

Deindividuation

Deindividuation is a form of social influence on an individual’s behavior such that the individual engages in unusual or non-normal behavior while in a group setting. Why? Because in these group settings, the individual no longer sees themselves as an individual anymore, disinhibiting their behavior and personal restraint.
tRNA Activation02:26

tRNA Activation

Aminoacyl-tRNA synthetases are present in both eukaryotes and bacteria. Though eukaryotes have 20 different aminoacyl-tRNA synthetases to couple to 20 amino acids, many bacteria do not have genes for all of these aminoacyl-tRNA synthetases. Despite this, they still use all 20 amino acids to synthesize their proteins. For instance, some bacteria do not have the gene encoding the enzyme that couples glutamine with its partner tRNA. In these organisms, one enzyme adds glutamic acid to all of the...
tRNA Activation02:26

tRNA Activation

Aminoacyl-tRNA synthetases are present in both eukaryotes and bacteria. Though eukaryotes have 20 different aminoacyl-tRNA synthetases to couple to 20 amino acids, many bacteria do not have genes for all of these aminoacyl-tRNA synthetases. Despite this, they still use all 20 amino acids to synthesize their proteins. For instance, some bacteria do not have the gene encoding the enzyme that couples glutamine with its partner tRNA. In these organisms, one enzyme adds glutamic acid to all of the...
Transient Ischemic Attack l: Introduction01:26

Transient Ischemic Attack l: Introduction

A transient ischemic attack (TIA) is a brief episode of neurological dysfunction caused by a temporary, focal reduction in cerebral blood flow. Although symptoms resemble those of an ischemic stroke, the interruption in perfusion is short-lived and does not cause permanent infarction. TIAs are clinically important because they often serve as early warning events for future stroke.Mechanisms of Transient Cerebral IschemiaTransient cerebral ischemia may arise through several mechanisms. One...
Hepatic Encephalopathy01:29

Hepatic Encephalopathy

DefinitionHepatic encephalopathy is a reversible neurologic syndrome that results from advanced liver dysfunction or portosystemic shunting. It leads to disturbances in cognition, behavior, and motor function due to the brain’s exposure to gut-derived toxins that the liver fails to detoxify.EtiologyThis condition develops either in the setting of acute fulminant hepatitis or progressively during chronic liver disease, such as cirrhosis and portal hypertension. Portosystemic shunting—including...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Caution in Interpreting Prognostic Genomic Factors in Underpowered Subgroups of Children with T-ALL.

Blood advances·2026
Same author

Oncogenic PIK3CA mutations shape an immunoregulatory microenvironment in mosaic overgrowth disorders.

PNAS nexus·2026
Same author

Thymic output in human newborns is shaped by environmental exposures and a common TCRD genetic variant.

Journal of human immunity·2026
Same author

Clonal Lymphocyte Expansions and JAK-STAT Pathway Mutations Define a Pathogenic Continuum Driving Resistance to Gluten-Free Diet in Celiac Disease.

Gastroenterology·2026
Same author

Contribution of a specific panel by flow cytometry for the differential diagnosis of plasmacytoid dendritic cell neoplasms.

Annals of hematology·2026
Same author

Homeodomain-driven oncogenic diversion to a γδTCR phenotype in T-cell acute lymphoblastic leukemia.

Blood·2026

Related Experiment Video

Updated: Jun 30, 2026

Combining Transcranial Magnetic Stimulation and fMRI to Examine the Default Mode Network
11:02

Combining Transcranial Magnetic Stimulation and fMRI to Examine the Default Mode Network

Published on: December 29, 2010

HiJAKing T-ALL.

Vahid Asnafi1

  • 1INSTITUT NECKER ENFANTS-MALADES U1151.

Blood
|November 15, 2014
PubMed
Summary
This summary is machine-generated.

Researchers explored the transforming potential of Janus kinase 3 (JAK3) mutations in T-cell acute lymphoblastic leukemia (T-ALL). This study supports the development of new therapies targeting both JAK1 and JAK3 in T-ALL patients.

More Related Videos

Transcranial Magnetic Stimulation for Investigating Causal Brain-behavioral Relationships and their Time Course
11:33

Transcranial Magnetic Stimulation for Investigating Causal Brain-behavioral Relationships and their Time Course

Published on: July 18, 2014

A Methodological Protocol and Considerations for Transcranial Ultrasonic Stimulation in Exploratory Clinical Human Studies
09:47

A Methodological Protocol and Considerations for Transcranial Ultrasonic Stimulation in Exploratory Clinical Human Studies

Published on: December 12, 2025

Related Experiment Videos

Last Updated: Jun 30, 2026

Combining Transcranial Magnetic Stimulation and fMRI to Examine the Default Mode Network
11:02

Combining Transcranial Magnetic Stimulation and fMRI to Examine the Default Mode Network

Published on: December 29, 2010

Transcranial Magnetic Stimulation for Investigating Causal Brain-behavioral Relationships and their Time Course
11:33

Transcranial Magnetic Stimulation for Investigating Causal Brain-behavioral Relationships and their Time Course

Published on: July 18, 2014

A Methodological Protocol and Considerations for Transcranial Ultrasonic Stimulation in Exploratory Clinical Human Studies
09:47

A Methodological Protocol and Considerations for Transcranial Ultrasonic Stimulation in Exploratory Clinical Human Studies

Published on: December 12, 2025

Area of Science:

  • Hematology
  • Oncology
  • Molecular Biology

Background:

  • T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematologic malignancy.
  • Janus kinase 3 (JAK3) signaling is crucial for lymphoid development and implicated in T-ALL pathogenesis.
  • Specific JAK3 mutations can confer transforming potential, driving leukemogenesis.

Purpose of the Study:

  • To investigate the functional consequences of identified JAK3 mutations in primary T-ALL samples.
  • To assess the transforming potential of these mutations in a cellular context.
  • To explore the therapeutic implications of targeting JAK3 and related kinases in T-ALL.

Main Methods:

  • Analysis of JAK3 mutations in primary T-ALL patient samples.
  • Functional assays to evaluate the transforming activity of mutated JAK3 proteins.
  • Assessment of cellular proliferation and survival in response to JAK inhibition.

Main Results:

  • Several JAK3 mutations identified in T-ALL samples exhibit transforming potential.
  • These mutations can lead to aberrant signaling and contribute to leukemic cell growth.
  • The findings highlight the role of JAK3 in T-ALL development.

Conclusions:

  • JAK3 mutations are oncogenic drivers in a subset of T-ALL.
  • Targeting JAK3, potentially in combination with JAK1, represents a promising therapeutic strategy for T-ALL.
  • Further research into multitargeted JAK inhibition is warranted for T-ALL treatment.