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Updated: Apr 21, 2026

Surfactant Depletion Combined with Injurious Ventilation Results in a Reproducible Model of the Acute Respiratory Distress Syndrome ARDS
Published on: April 7, 2021
Low Tidal Volume Ventilation in Patients Without Acute Lung Injury
Weibing Tang1, Zhi Wang2, Ye Liu1
1Department of Intensive Care, the 208th Hospital of PLA, 4799 Xian Road, Changchun, 130062, China.
Abstract:
Acute respiratory distress syndrome is a life threatening respiratory condition characterized by breakdown of the alveolar-capillary barrier, leading to flooding of the alveolar space producing the classical chest radiograph of bilateral pulmonary infiltrates. In this study, we employed lung protective ventilation strategies in patients without acute lung injury (ALI) to determine whether mechanical ventilation with lower tidal volume would provide more clinical benefits to patients without ALI.
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