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Related Concept Videos

Kidney Transplant I: Introduction01:28

Kidney Transplant I: Introduction

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A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
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Kidney Transplant II: Surgical Procedure01:26

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Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living...
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Postoperative Nursing Management for Kidney Transplant PatientsPostoperative nursing management care includes monitoring the surgical site, encouraging early movement, and promoting lung health through breathing exercises. Nurses also administer prescribed medications like H2-blockers, such as famotidine, or proton pump inhibitors, like omeprazole, to help prevent gastrointestinal ulcers and bleeding. Fungal infections in the mouth and bladder can result from immunosuppressive and antibiotic...
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Tissue Transplantation01:24

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Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
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Bone Marrow Sampling and Transplants01:22

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Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
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Reduced Complications after Arterial Reconnection in a Rat Model of Orthotopic Liver Transplantation
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Developing trends in the intestinal transplant waitlist.

K M Khan1, C S Desai, M Mete

  • 1Transplant Institute, MedStar Georgetown University Hospital, Washington, DC.

American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons
|November 15, 2014
PubMed
Summary
This summary is machine-generated.

Trends in intestinal transplantation (ITx) waitlists show a significant shift in 2006, with liver-intestine transplants (L-ITx) driving changes. Improved infant care reduced L-ITx referrals, impacting overall waitlist dynamics.

Keywords:
Clinical research/practiceOrgan Procurement and Transplantation Network (OPTN)intestine/multivisceral transplantationwaitlist management

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Area of Science:

  • Transplantation research
  • Organ donation and transplantation statistics
  • Pediatric surgery

Background:

  • The United Network for Organ Sharing (UNOS) database tracks organ transplant waitlists.
  • Intestinal transplantation (ITx) includes isolated ITx and combined liver-intestine transplants (L-ITx).
  • Understanding waitlist trends is crucial for resource allocation and patient management.

Purpose of the Study:

  • To analyze trends in the ITx waitlist from 1993 to 2012.
  • To differentiate trends between isolated ITx and L-ITx.
  • To identify factors influencing waitlist dynamics, particularly in pediatric populations.

Main Methods:

  • Retrospective analysis of the UNOS database from 1993 to 2012.
  • Categorization of waitlist registrants into isolated ITx and L-ITx.
  • Spline modeling to identify significant trend changes in waitlist registration.

Main Results:

  • Waitlist registrants peaked in 2006, with a significant trend change (p < 0.001).
  • L-ITx constituted the largest proportion of new registrants, showing a highly significant trend change in 2006 (p < 0.001).
  • Waitlist mortality peaked around 2002, highest for L-ITx in infants and adults, though pediatric deaths have decreased.

Conclusions:

  • The ITx waitlist experienced a significant trend shift in 2006, primarily driven by L-ITx, especially in infants.
  • Improved management of intestinal failure in infants has led to decreased referrals for L-ITx.
  • While waitlist mortality has seen some improvements, particularly in pediatric L-ITx, continued monitoring is essential.