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Esophageal cancer: Recent advances in screening, targeted therapy, and management
Puja Gaur1, Min P Kim1, Brian J Dunkin2
1Department of Thoracic Surgery, Weill Cornell Medical College of Cornell University, Houston Methodist Hospital, 6550 Fannin Street, Suite 1661, Houston, TX 77030, USA ; Department of General Surgery, Weill Cornell Medical College of Cornell University, Houston Methodist Hospital, 6550 Fannin Street, Suite 1661, Houston, TX 77030, USA.
Abstract:
The incidence of esophageal cancer remains on the rise worldwide and despite aggressive research in the field of gastrointestinal oncology, the survival remains poor. Much remains to be defined in esophageal cancer, including the development of an effective screening tool, identifying a good tumor marker for surveillance purposes, ways to target esophageal cancer stem cells as well as circulating tumor cells, and developing minimally invasive protocols to treat early-stage disease. The goal of this chapter is to highlight some of the recent advances and ongoing research in the field of esophageal cancer.
Insights
Esophageal cancer incidence is increasing globally, with poor survival rates. This chapter reviews recent advances and ongoing research in esophageal cancer, focusing on screening, biomarkers, and treatment strategies.
Area of Science:
- Gastrointestinal Oncology
- Cancer Research
Background:
- Global incidence of esophageal cancer is rising.
- Survival rates for esophageal cancer remain poor despite extensive research.
- Significant knowledge gaps exist in esophageal cancer management.
Purpose of the Study:
- To highlight recent advances in esophageal cancer research.
- To discuss ongoing research directions in the field.
Main Methods:
- Review of current literature and ongoing research in esophageal cancer.
- Focus on key areas including screening, biomarkers, and therapeutic strategies.
Main Results:
- Advances in identifying effective screening tools are needed.
- Development of reliable tumor markers for surveillance is crucial.
- Targeting esophageal cancer stem cells and circulating tumor cells shows promise.
- Minimally invasive treatment protocols for early-stage disease are under development.
Conclusions:
- Continued research is essential to improve esophageal cancer outcomes.
- Addressing screening, surveillance, and treatment remains a priority.
- Novel therapeutic strategies are emerging for esophageal cancer.
