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Genetic susceptibility, somatic mosaicisms and predisposition to human cancer
S Pathak1, M K Dhaliwal, V L Hopwood
1Department of Cell Biology, University of Texas M.D. Anderson Cancer Center, Houston 77030.
Anticancer Research
|January 1, 1989
Abstract:
We herein propose that specific chromosomal aberrations associated with specific neoplasms are not necessarily inherited as a constitutional trait. High-risk individuals may have a tendency to undergo specific somatic mutations or chromosomal rearrangements at a relatively low frequency in all tissues as mosaicism. This may potentiate the development of specific somatic cancers. Our hypothesis may be applicable to both hereditary and sporadic types of neoplasms.