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Visual outcome and incidence of glaucoma in patients with microspherophakia

R Muralidhar1, K Ankush1, P Vijayalakshmi1

  • 1Department of Pediatric Ophthalmology, Aravind Eye Hospital, Madurai, India.

Eye (London, England)
|November 15, 2014
PubMed
Abstract

Insights

Microspherophakia frequently causes myopia, lens dislocation, and glaucoma. Managing glaucoma in these patients is challenging, often resulting in persistently high intraocular pressure (IOP) despite treatment.

Area of Science:

  • Ophthalmology
  • Genetics

Background:

  • Microspherophakia is a rare condition with poorly understood complication incidence.
  • Existing literature primarily consists of small case reports.

Purpose of the Study:

  • To describe ocular complications in a series of patients with microspherophakia.
  • To determine the incidence of complications and evaluate management outcomes.

Main Methods:

  • Retrospective analysis of clinical and surgical findings.
  • Review of 36 eyes from 18 patients diagnosed with microspherophakia between 1998 and 2008.

Main Results:

  • High incidence of lenticular myopia (mean -11.07D) and lens subluxation requiring lensectomy (44.4%).
  • Glaucoma developed in 44.4% of eyes, with persistent high IOP in 5 eyes post-treatment.
  • Homocysteinuria was the most common systemic association.

Conclusions:

  • Microspherophakia is significantly associated with myopia, lens subluxation, and glaucoma.
  • Glaucoma management in microspherophakia is challenging, with limited success in normalizing IOP.
  • Lensectomy did not impact intraocular pressure in the studied cohort.

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