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Chronic neonatal coxsackie myocarditis
1Department of Neonatology, Shaare Zedek Medical Center, Hebrew University-Hadassah Medical School, Jerusalem, Israel.
Archives of Disease in Childhood
|March 1, 1989
Insights
A newborn developed severe myocarditis and permanent myocardial calcification due to Coxsackie virus B1 infection. This infant
Area of Science:
- Neonatal cardiology
- Pediatric infectious diseases
- Viral myocarditis
Background:
- Neonatal myocarditis is a serious condition.
- Coxsackie B viruses are a common cause of viral infections in neonates.
- Myocardial calcification can occur in severe cases.
Observation:
- A baby girl with a birth weight of 2540 g developed myocarditis.
- Gross, permanent myocardial calcification was observed.
- The infant's clinical course was progressively downhill, leading to death at 14 months of age.
Findings:
- Neutralizing antibody titers to Coxsackie virus group B1 rose significantly.
- The patient exhibited a protracted disease course.
- This case represents a novel clinical presentation of fatal neonatal Coxsackie B virus infection.
Implications:
- This case highlights a new clinical form of fatal neonatal Coxsackie B virus infection.
- Understanding this protracted course is crucial for diagnosis and management.
- Further research into the pathogenesis of neonatal Coxsackie B virus infection is warranted.
Abstract:
A baby girl, with a birth weight of 2540 g, developed myocarditis with gross, permanent myocardial calcification. The clinical course was progressively downhill, and she died at 14 months of age. Neutralisation antibody to Coxsackie virus group B1 rose from 1:80 after delivery to 1:1280 at age 5 months. The protracted course of this infant's disease represents a new clinical form of fatal neonatal Coxsackie virus group B infection.