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Related Experiment Video

Updated: Apr 20, 2026

Author Spotlight: Overcoming Anti-VEGF Resistance Through Advanced Vascular Morphology Assessment in Choroidal Neovascularization

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Published on: August 11, 2023

Multimodality imaging in diagnosing polypoidal choroidal vasculopathy.

Jie Zhang¹, Zikui Yu, Lin Liu

¹*MD Department of Ophthalmology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China (all authors).

Optometry and Vision Science : Official Publication of the American Academy of Optometry

|November 15, 2014

Summary

Multispectral imaging (MSI) offers a novel, noninvasive method for detecting polypoidal choroidal vasculopathy (PCV). This technique effectively visualizes deep retinal structures, aiding in PCV diagnosis.

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Novel Photoacoustic Microscopy and Optical Coherence Tomography Dual-modality Chorioretinal Imaging in Living Rabbit Eyes

Novel Photoacoustic Microscopy and Optical Coherence Tomography Dual-modality Chorioretinal Imaging in Living Rabbit Eyes

Published on: February 8, 2018

Area of Science:

Ophthalmology
Medical Imaging

Background:

Polypoidal choroidal vasculopathy (PCV) is a subtype of neovascular age-related macular degeneration.
Accurate diagnosis of PCV is crucial for effective treatment and management.

Observation:

A case of PCV in a 60-year-old Chinese woman presenting with blurred vision and subretinal hemorrhage.
Fundus examination revealed polyp-like structures, and OCT showed the characteristic "double-layer" sign.

Findings:

Indocyanine green angiography confirmed PCV features, including polyps and ringlike staining.
Multispectral imaging (MSI) visualized polypoidal lesions as hyperreflective clusters, particularly in longer-wavelength images, correlating with ICG angiography.

Implications:

MSI presents a promising, noninvasive imaging modality for PCV detection.
The simplicity and effectiveness of MSI suggest its potential utility in routine clinical diagnosis of PCV.