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Bringing in the cavalry: IL-26 mediates neutrophil recruitment to the lungs

Kristin L Griffiths1, Shabaana A Khader

  • 11 Department of Molecular Microbiology Washington University in St. Louis St. Louis, Missouri.

American Journal of Respiratory and Critical Care Medicine
|November 15, 2014
PubMed
Abstract

No abstract available in PubMed .

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The cellular phase of acute inflammation is a tightly orchestrated sequence of events that recruits leukocytes, primarily neutrophils, to sites of tissue injury or infection. Following the initial vascular changes, this phase ensures effective immune cell migration, activation, and function at the affected site to eliminate pathogens and initiate tissue repair.Leukocyte Recruitment CascadeLeukocyte recruitment happens in four steps: margination, adhesion, transmigration, and chemotaxis. Reduced...
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