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Intrauterine device may trigger typical attacks of familial Mediterranean fever: a case report

Ilhan Kurultak1, Can Kinalp, Mevlut Ceri

  • 1Department of Nephrology, Gulhane Military Academy of Medicine, Haydarpasa Training Hospital, Istanbul, Turkey, ilhankurultak@yahoo.co.uk.

Wiener Klinische Wochenschrift
|November 16, 2014
PubMed

Insights

Familial Mediterranean fever (FMF) attacks can be triggered by intrauterine devices (IUDs). This case suggests copper IUDs may initiate systemic inflammation, causing FMF flares in susceptible women.

Area of Science:

  • Genetics and Immunology
  • Reproductive Health

Background:

  • Familial Mediterranean fever (FMF) is an autosomal recessive autoinflammatory disorder causing recurrent fever and serositis.
  • Intrauterine devices (IUDs) are common, safe, and effective contraceptives used globally.

Observation:

  • A case report details a woman with FMF whose inflammatory attacks were initiated by a copper-containing IUD.
  • The copper IUD may induce localized uterine inflammation, potentially triggering systemic inflammatory responses in FMF patients.

Findings:

  • This is the first reported instance of a copper IUD triggering FMF attacks.
  • The mechanism proposed involves sterile uterine inflammation from the IUD acting as a systemic inflammatory trigger.

Implications:

  • Clinicians should consider copper IUDs as a potential trigger for FMF attacks in women using this contraceptive method.
  • Further research may elucidate the precise inflammatory pathways linking IUDs to FMF exacerbations.

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