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Thyroid hormone action and the erbA oncogene family
Y Goldberg1, C Glineur, R Bosselut
1INSERM U186/CNRS UA1160, Institut Pasteur de Lille, France.
Biochimie
|February 1, 1989
Summary
This review covers the v-erbA oncogene and c-erbA proto-oncogene products, highlighting their roles as thyroid hormone receptors and their relation to nuclear hormone receptor structure and function.
Area of Science:
- Molecular Biology
- Oncology
- Endocrinology
Background:
- The v-erbA oncogene is implicated in cellular transformation.
- Proto-oncogenes like c-erbA play crucial roles in normal cellular processes.
- Nuclear hormone receptors are key regulators of gene expression.
Purpose of the Study:
- To review the biological actions and biochemical functions of the v-erbA oncogene product.
- To elucidate the role of c-erbA proto-oncogene products as thyroid hormone receptors.
- To examine the broader context of nuclear hormone receptor structure and function.
Main Methods:
- Literature review of existing research on v-erbA and c-erbA.
- Analysis of molecular structures and biochemical functions.
- Comparative study of oncogene and proto-oncogene products.
Main Results:
- The v-erbA oncogene product exhibits distinct biological activities.
- c-erbA proto-oncogene products function as thyroid hormone receptors.
- Understanding these proteins provides insights into nuclear hormone receptor mechanisms.
Conclusions:
- The v-erbA oncogene product's function is linked to cellular signaling pathways.
- c-erbA's role as a thyroid hormone receptor is critical for metabolic regulation.
- This review consolidates knowledge on oncogenes, proto-oncogenes, and nuclear hormone receptors.
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