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Related Concept Videos

Endocarditis II: Clinical Features of Infective Endocarditis01:25

Endocarditis II: Clinical Features of Infective Endocarditis

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Endocarditis can present various clinical features depending on the causative organism and the patient's underlying health conditions. Initially, the clinical features of infective endocarditis develop gradually, presenting with nonspecific symptoms that can be easily mistaken for other illnesses.General SymptomsEarly symptoms of infective endocarditis are fever, chills, weakness, malaise, fatigue, and weight loss. These symptoms reflect the systemic nature of the infection and the body's...
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Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
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Dermis
The dermis might be considered the "core" of the integumentary system, as distinct from the epidermis and hypodermis. It contains blood and lymph vessels, nerves, and other structures, such as hair follicles and sweat glands. The dermis is made of two layers of connective tissue that comprise an interconnected mesh of elastin and collagenous fibers, produced by fibroblasts.
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The papillary and reticular dermis are the two layers of the dermis. They are made of connective tissue with fibers of collagen extending from one to the other, making the border between the two somewhat indistinct. The dermal papillae extending into the epidermis belong to the papillary layer, whereas the dense collagen fiber bundles below belong to the reticular layer.
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Related Experiment Video

Updated: Apr 20, 2026

Dermoscopy Aids in the Diagnosis of Discoid Lupus Erythematosus
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Erythema nodosum.

John A Vigilante, Jane Scribner

    Journal of Special Operations Medicine : a Peer Reviewed Journal for SOF Medical Professionals
    |November 17, 2014
    PubMed
    Summary

    Erythema nodosum (EN) presents as tender leg nodules and is usually self-limiting. However, EN can indicate underlying medical conditions requiring further investigation.

    Area of Science:

    • Dermatology
    • Internal Medicine

    Background:

    • Erythema nodosum (EN) is an inflammatory condition affecting subcutaneous fat.
    • It typically manifests as tender, red nodules, often on the anterior legs.

    Observation:

    • A case study of an active duty female Sailor presenting with leg nodules.
    • Symptoms began 1.5 weeks prior to clinical visit.

    Findings:

    • Diagnosis of erythema nodosum (EN).
    • EN is generally self-limiting but can signal other medical issues.

    Implications:

    • Highlights the importance of considering underlying diagnoses in EN cases.
    • Reviews pathophysiology, causes, diagnosis, and management of EN.

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