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Updated: Apr 20, 2026

Identification of Mediators of T-cell Receptor Signaling via the Screening of Chemical Inhibitor Libraries
Published on: January 22, 2019
Protein kinase Cθ: the pleiotropic T-cell signalling intermediate
Katarzyna Wachowicz1, Gottfried Baier1
1*Translational Cell Genetics, Department of Pharmacology and Genetics, Medical University of Innsbruck, Peter Mayr Strasse 1a, A-6020 Innsbruck, Austria.
Abstract:
Activating as well as inhibitory circuits tightly regulate T-cell activation thresholds and effector differentiation processes enabling proper immune response outcomes. Recently, an additional molecular link between T-cell receptor signalling and CD4⁺ Th17 cell skewing has been reported, namely that protein kinase C (PKC) θ critically regulates Th17/Th1 phenotypic differentiation and plasticity in CD4⁺ T-cells by selectively acting as a 'reprogramming element' that suppresses Th1-typical genes during Th17-mediated immune activation in order to stabilize a Th17 cell phenotype.
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