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Published on: February 21, 2019
Protein kinase C in cellular transformation: a valid target for therapy?
Anuradha Tarafdar1, Alison M Michie1
1*Paul O'Gorman Leukaemia Research Centre, Institute of Cancer Sciences, University of Glasgow, 21 Shelley Road, Glasgow G12 02D, U.K.
Protein Kinase C (PKC) isoforms are implicated in chronic lymphocytic leukemia (CLL) cell survival. Targeting these PKC signaling pathways linked to the B-cell receptor (BCR) may offer new therapeutic strategies for CLL.
Area of Science:
- Biochemistry
- Molecular Biology
- Oncology
Background:
- Protein Kinase C (PKC) is a family of enzymes with diverse functions.
- PKC isoforms are widely distributed, complicating the study of individual roles.
- PKC involvement in leukemia cell survival and proliferation is suggested.
Purpose of the Study:
- To review the role of PKC isoforms in chronic lymphocytic leukemia (CLL) pathophysiology.
- To assess therapeutic strategies targeting PKC activity in CLL.
Main Methods:
- Literature review of studies on PKC isoforms in CLL.
- Analysis of PKC isoform involvement in B-cell receptor (BCR) signaling.
- Evaluation of therapeutic approaches modulating PKC activity.
Main Results:
- PKC isoforms, particularly PKCβ and δ, are crucial for B-cell development.
- These PKC isoforms link the BCR to downstream signaling pathways.
- Dysregulated PKC isoform expression is observed in CLL.
Conclusions:
- PKC isoforms play a significant role in CLL pathophysiology.
- Modulating BCR/PKC signaling pathways presents a potential therapeutic avenue for CLL.
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