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Related Concept Videos

Human Genetics01:28

Human Genetics

2.0K
Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
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Behavioral Genetics and Its Designs01:23

Behavioral Genetics and Its Designs

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Behavior genetics explores how genetic inheritance influences human behavior. It focuses on how genes, passed from parents to offspring, contribute to the development of behavioral traits and tendencies. This branch of genetics seeks to understand the complex interplay between inherited genetic factors and environmental influences in shaping our behaviors.
The primary methodologies used in behavior genetics include family studies, twin studies, and adoption studies, each providing unique...
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Genetic Lingo01:11

Genetic Lingo

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Overview
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Principles of Pharmacogenetics: Types of Genetic Variants01:27

Principles of Pharmacogenetics: Types of Genetic Variants

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The human genome is over 99.9% identical between individuals, yet genetic differences exist at millions of bases. The human genome contains approximately 3 million variant positions per individual, many of which are heterozygous, contributing to genetic diversity and individual traits. Genetic variations include single-nucleotide polymorphisms (SNPs), insertions, deletions, and copy number variations (CNVs).SNPs, the most common variation, involve single-base changes in DNA. These can be...
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Pharmacogenetic Phenotypes: Alterations in Pharmacokinetics, Drug Targets and Biologic Milieu01:29

Pharmacogenetic Phenotypes: Alterations in Pharmacokinetics, Drug Targets and Biologic Milieu

142
Genetic variations significantly influence drug response through pharmacokinetics, receptor interactions, and biologic milieu modifications. Pharmacokinetic alterations impact drug metabolism and clearance, affecting efficacy and toxicity. Variants in drug-metabolizing enzymes, such as CYP2C9 and CYP2C19, alter drug activation and elimination. For example, CYP2C9 loss-of-function variants require lower warfarin doses to prevent excessive bleeding, while CYP2C19 variants reduce clopidogrel...
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Incomplete Dominance01:43

Incomplete Dominance

32.9K
Gregor Mendel's work (1822 - 1884) was primarily focused on pea plants. Through his initial experiments, he determined that every gene in a diploid cell has two variants called alleles inherited from each parent. He suggested that amongst these two alleles, one allele is dominant in character and the other recessive. The combination of alleles determines the phenotype of a gene in an organism.
32.9K

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Related Experiment Video

Updated: Apr 20, 2026

An Inexpensive, Scalable Behavioral Assay for Measuring Ethanol Sedation Sensitivity and Rapid Tolerance in Drosophila
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An Inexpensive, Scalable Behavioral Assay for Measuring Ethanol Sedation Sensitivity and Rapid Tolerance in Drosophila

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Genetics of alcoholism.

Priya A Iyer-Eimerbrink1, John I Nurnberger

  • 1Institute of Psychiatric Research, Department of Psychiatry, School of Medicine, Indiana University, 320 W. 15th Street, Indianapolis, IN, 46202, USA, piyereim@iupui.edu.

Current Psychiatry Reports
|November 18, 2014
PubMed
Summary

Genetic factors significantly influence alcohol use and alcohol use disorders. Research highlights specific genes, polygenic risk scores, and gene-environment interactions in understanding alcoholism heritability.

Area of Science:

  • Genetics
  • Neuroscience
  • Psychiatry

Background:

  • Alcohol use disorders (AUDs) exhibit substantial heritability.
  • Genetic variants in alcohol metabolic enzymes and specific genes (e.g., GABRA2, CHRNB3) are linked to alcohol consumption and AUDs.

Purpose of the Study:

  • To provide an overview of current findings in the genetics of alcoholism.
  • To identify areas requiring further research in understanding the genetic architecture of AUDs.

Main Methods:

  • Review of genetic analyses, including polygenic risk scores.
  • Examination of neurobiological pathways and gene-environment interactions.
  • Inclusion of behavioral traits (impulsivity, sensation seeking) and demographic factors (sex, ethnicity).

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High-Throughput Method for Measuring Alcohol Sedation Time of Individual Drosophila melanogaster
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High-Throughput Method for Measuring Alcohol Sedation Time of Individual Drosophila melanogaster

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Murine Drinking Models in the Development of Pharmacotherapies for Alcoholism: Drinking in the Dark and Two-bottle Choice
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Murine Drinking Models in the Development of Pharmacotherapies for Alcoholism: Drinking in the Dark and Two-bottle Choice

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Related Experiment Videos

Last Updated: Apr 20, 2026

An Inexpensive, Scalable Behavioral Assay for Measuring Ethanol Sedation Sensitivity and Rapid Tolerance in Drosophila
07:28

An Inexpensive, Scalable Behavioral Assay for Measuring Ethanol Sedation Sensitivity and Rapid Tolerance in Drosophila

Published on: April 15, 2015

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High-Throughput Method for Measuring Alcohol Sedation Time of Individual Drosophila melanogaster
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High-Throughput Method for Measuring Alcohol Sedation Time of Individual Drosophila melanogaster

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Murine Drinking Models in the Development of Pharmacotherapies for Alcoholism: Drinking in the Dark and Two-bottle Choice
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Murine Drinking Models in the Development of Pharmacotherapies for Alcoholism: Drinking in the Dark and Two-bottle Choice

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Main Results:

  • Heritability of alcohol use and AUDs is well-established.
  • Specific genes and genetic pathways are associated with increased risk.
  • Gene-gene and gene-environment interactions play a crucial role.

Conclusions:

  • The genetic architecture of AUDs is complex, involving multiple genes and environmental factors.
  • Continued research is needed to fully elucidate the genetic underpinnings of alcoholism.
  • Understanding genetic influences can inform prevention and treatment strategies.