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How does magnetization transfer influence mcDESPOT results?

Jing Zhang1, Shannon H Kolind2, Cornelia Laule1,3

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Magnetic Resonance in Medicine
|November 18, 2014
PubMed
Summary
This summary is machine-generated.

Magnetization transfer (MT) affects signals in multicomponent driven equilibrium single pulse observation of T1 and T2 (mcDESPOT) imaging. However, the extracted myelin water fraction values remain largely unaffected by MT changes.

Keywords:
T2 relaxationmagnetization transfermyelin water fractionsteady-state imaging

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Area of Science:

  • Neuroimaging
  • Biophysics

Background:

  • Multicomponent driven equilibrium single pulse observation of T1 and T2 (mcDESPOT) is a novel method for myelin water fraction (fM) mapping.
  • mcDESPOT-derived fM values are often higher than those from other techniques.
  • Magnetization transfer (MT) effects from radiofrequency pulses may influence mcDESPOT fM estimates.

Purpose of the Study:

  • To investigate the impact of Magnetization Transfer (MT) on mcDESPOT imaging.
  • To determine if MT influences myelin water fraction (fM) measurements obtained via mcDESPOT.

Main Methods:

  • mcDESPOT data acquired from healthy volunteers using two pulse types: short (high MT) and long (low MT).
  • Comparison of MR parameters between white and gray matter regions using paired t-tests.
  • Analysis of whole-slice difference images to assess MT effects.

Main Results:

  • MT significantly influenced the signal in mcDESPOT balanced steady-state free precession sequences.
  • Observed MT effects were not clearly apparent in the fM values calculated using standard mcDESPOT analysis.
  • Myelin water fraction values showed relative insensitivity to variations in MT.

Conclusions:

  • The signal in mcDESPOT is sensitive to Magnetization Transfer (MT).
  • Extracted myelin water fraction values from mcDESPOT are relatively robust to MT variations.
  • Further investigation may be needed to fully understand the interplay between MT and mcDESPOT in specific applications.