Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Potential bronchoconstrictor stimuli in acid fog.

J R Balmes1, J M Fine, T Gordon

  • 1Lung Biology Center, Northern California Occupational Health Center, San Francisco.

Environmental Health Perspectives
|February 1, 1989
PubMed
Summary

Acid fog components can trigger bronchoconstriction in asthmatics. Titratable acidity and sulfites are key stimuli, with acidity potentially worsening fog-induced airway narrowing.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Spontaneous Escherichia coli Meningitis and Pyogenic Ventriculitis in an Adult Receiving Anti-Tumour Necrosis Factor Alpha Therapy.

Irish medical journal·2022
Same author

Household air pollution and COPD: cause and effect or confounding by other aspects of poverty?

The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease·2022
Same author

Effects of short-term increases in personal and ambient pollutant concentrations on pulmonary and cardiovascular function: A panel study analysis of the Multicenter Ozone Study in oldEr subjects (MOSES 2).

Environmental research·2021
Same author

Multicenter Ozone Study in oldEr Subjects (MOSES): Part 2. Effects of Personal and Ambient Concentrations of Ozone and Other Pollutants on Cardiovascular and Pulmonary Function.

Research report (Health Effects Institute)·2020
Same author

Multicenter Ozone Study in oldEr Subjects (MOSES): Part 1. Effects of Exposure to Low Concentrations of Ozone on Respiratory and Cardiovascular Outcomes.

Research report (Health Effects Institute)·2020
Same author

α-PD-1 therapy elevates Treg/Th balance and increases tumor cell pSmad3 that are both targeted by α-TGFβ antibody to promote durable rejection and immunity in squamous cell carcinomas.

Journal for immunotherapy of cancer·2019

Area of Science:

  • Environmental Health
  • Pulmonary Medicine
  • Atmospheric Chemistry

Background:

  • Acid fog comprises numerous stimuli, including inorganic acids, sulfites, hypoosmolar aerosols, and gaseous pollutants.
  • These components may individually or interactively induce bronchoconstriction, posing risks to respiratory health, particularly in individuals with asthma.

Purpose of the Study:

  • To evaluate the bronchoconstrictor potency of individual acid fog stimuli.
  • To investigate potential interactions among these stimuli in subjects with asthma.
  • To determine the relative importance of different chemical properties, such as titratable acidity versus pH, in triggering respiratory responses.

Main Methods:

  • Characterization of bronchoconstrictor potency of acid fog components in human subjects, specifically those with asthma.
  • Assessment of interactions between different stimuli, including acidity, sulfites, and hypoosmolar aerosols.
  • Inhalation studies exposing subjects to various fog components and measuring respiratory effects.

Main Results:

  • Titratable acidity was identified as a more significant bronchoconstrictor stimulus than pH.
  • Sulfite species were found to induce bronchoconstriction, especially under acidic conditions.
  • Acidity was shown to potentiate bronchoconstriction caused by hypoosmolar fog.

Conclusions:

  • The complex mixture of stimuli in acid fog contributes to respiratory health effects.
  • Titratable acidity and sulfites are key contributors to acid fog-induced bronchoconstriction.
  • Acidity plays a crucial role in exacerbating airway narrowing, particularly in asthmatic individuals.

Related Experiment Videos