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[Myocardial protective effect of Danhong Injection evaluated by velocity vector imaging in patients undergoing
Jing Dong1, Yundai Chen2, Guang Zhi
1Department of Cardiology, General PLA Hospital, Beijing 100853, China.
Insights
Danhong Injection demonstrated a myocardial protective effect in patients undergoing percutaneous coronary intervention (PCI). This traditional Chinese medicine improved cardiac function and reduced myocardial injury markers post-PCI.
Area of Science:
- Cardiology
- Pharmacology
- Medical Imaging
Background:
- Unstable angina pectoris (UAP) poses significant risks, especially after percutaneous coronary intervention (PCI).
- Assessing myocardial protection and regional systolic function is crucial for managing UAP patients post-PCI.
Purpose of the Study:
- To evaluate the myocardial protective effects of Danhong Injection in UAP patients after PCI using Velocity Vector Imaging (VVI).
- To elucidate the potential mechanism behind Danhong Injection's cardioprotective action.
Main Methods:
- A randomized controlled trial involving 120 UAP patients undergoing PCI.
- Patients received either standard care (control group) or standard care plus Danhong Injection (Danhong group).
- Myocardial injury markers (CK-MB, cTnT) and regional systolic function (VVI) were assessed pre- and post-PCI.
Main Results:
- The Danhong group showed significantly lower levels of CK-MB and cTnT compared to the control group post-PCI.
- Velocity Vector Imaging revealed improved strain and strain rate in multiple myocardial segments in the Danhong group.
- These findings indicate enhanced segmental systolic function in patients treated with Danhong Injection.
Conclusions:
- Peri-procedural administration of Danhong Injection effectively mitigates myocardial injury following PCI.
- Danhong Injection demonstrably improves segmental systolic function in patients with unstable angina pectoris.
- VVI serves as a valuable tool for evaluating the efficacy of interventions like Danhong Injection in preserving myocardial function.
Objective:
To observe the myocardial protective effect of Danhong Injection evaluated by velocity vector imaging (VVI) in patients with unstable angina pectoris after percutaneous coronary intervention (PCI) and elucidate its possible mechanism.
Methods:
A total of 120 patients were randomized into Danhong (DG, n = 60) or control (CG, n = 60) groups. The patients in CG group received regular medication according to the guidelines while those in DG group regular medication plus Danhong Injection before and after PCI. During PCI, 40 ml Danhong Injection was administrated intravenously. The levels of CK-MB and cTnT were tested before and 24 hours after PCI. And VVI was performed before and 24 hours after PCI.
Results:
After treatment with Danhong injection, the serum level of MB isoenzyme of creatine kinase (CK-MB) and cardiac troponin T (cTnT) in DG were lower than those in CG (18.19 ± 10.23 vs 25.12 ± 11.91,0.079 ± 0.007 vs 0.132 ± 0.011, P < 0.05). Meanwhile, strain and strain rate of interventricular septum apex, anterior apex, inferior basement and inferior middle segment were better in DG than those in CG (26.01 ± 7.94 vs 23.25 ± 6.68, 20.91 ± 7.55 vs 18.79 ± 8.45, 18.10 ± 7.31 vs 16.89 ± 6.05, 21.16 ± 6.42 vs 18.37 ± 6.54, P < 0.05; 1.93 ± 0.79 vs 1.69 ± 0.63, 1.86 ± 0.72 vs 1.63 ± 0.68, 1.51 ± 0.80 vs 1.25 ± 0.54, 1.50 ± 0.45 vs 1.33 ± 0.32, P < 0.05 respectively).
Conclusion:
Peri-procedual Danhong injection can ameliorate myocardial injury and improve segmental systolic function.
