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[Study on the reference range of reticulocyte multi-parameter in newborn from Beijing]
Rui Chen1, Haibin Li1, Xin Zhang1
1Department of Clinical Laboratory, Beijing Tongren Hospital Affiliated to Capital Medical University, Beijing 100760, China.
Zhonghua Yi Xue Za Zhi
|November 18, 2014
Summary
Reference values for Reticulocyte (RET) counts in newborns vary by sex and age. Male newborns have lower RET percentages than females, and RET levels change significantly with the day age of the infant.
Area of Science:
- Neonatal Medicine
- Hematology
- Pediatrics
Background:
- Reticulocyte (RET) counts are crucial indicators of erythropoiesis in newborns.
- Establishing accurate reference ranges for RET in neonates is essential for clinical interpretation.
Purpose of the Study:
- To determine the reference values for Reticulocyte (RET) counts in Beijing newborns.
- To investigate the relationship between RET levels and the postnatal day age of infants.
Main Methods:
- Analysis of RET percentages in 2,759 healthy newborns using the XE-2100 analyzer.
- Statistical analysis included inverse sine transformation, independent sample t-tests, and ANOVA.
- Newborns were grouped by day age, with comparisons made between genders and age groups.
Main Results:
- Normal RET reference values were established: 2.408%-3.438% for males and 2.740%-3.912% for females.
- Male newborns exhibited significantly lower RET counts than females (P < 0.05).
- Significant differences in RET counts were observed across different day ages for both sexes (P < 0.01), with a notable peak value.
Conclusions:
- Newborn RET values differ significantly between sexes and change dynamically with postnatal age.
- These established reference ranges for RET in newborns of different genders and ages are valuable for clinical diagnosis and treatment.
