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[Expression of CCDC67 mRNA and its role in patients with papillary thyroid carcinoma]
Detao Yin1, Jianhui Xu, Yongfei Wang
1Department of Thyroid Surgery, First Affiliated Hospital, Zhengzhou University, Key-Discipline Laboratory Clinical Medicine, Zhengzhou 450052, China.
Objective:
To explore the expression of CCDC67 mRNA between papillary thyroid carcinoma (PTC) and adjacent normal tissues.
Methods:
Reverse transcription-polymerase chain reaction (RT-PCR) was employed to detect the expression of CCDC67 mRNA in 48 cases of papillary thyroid carcinoma and their matched adjacent non-cancerous epithelium and cell lines of thyroid carcinoma.
Results:
There was no expression of CCDC67 mRNA in SW579 and TPC-1 cell line. All cases had the expression of CCDC67 in adjacent normal tissues while the expression of CCDC67 mRNA was down-regulated significantly, only 39.6% (19/48) in 48 cases of thyroid carcinoma. In PTC, the expression rates of CCDC67 mRNA in stage I-II and III-IV were 60% (12/20) and 25% (7/28) and 24.1% (7/29) and 63.2% (12/19) in the lymph node metastasis and non-metastasis groups respectively. Also the expression rates of CCDC67 mRNA in Grades I and II were 61.1% (11/18) and 26.7% (8/30) respectively. And there was significant difference between two groups (P < 0.05).
Conclusions:
The down-regulated expression of CCDC67 is one of reasons for inactivation of PTC. And it may play an important role in carcinogenesis and progression of PTC.
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