Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Alzheimer Disease l: Introduction01:29

Alzheimer Disease l: Introduction

6
Alzheimer disease is a chronic, progressive, and irreversible neurodegenerative disorder and the most common cause of dementia in older adults. It leads to gradual neuronal loss, causing cognitive decline, behavioral changes, and loss of functional independence.Risk Factors and EtiologyThe disease is multifactorial. Age is the strongest risk factor, with prevalence doubling every 5 years after age 65. Genetic factors include mutations in genes such as APP, PSEN1, and PSEN2, which are associated...
6
Aging01:26

Aging

1.1K
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
1.1K
Pharmacodynamics in Geriatric Patients: Effects of Age01:27

Pharmacodynamics in Geriatric Patients: Effects of Age

349
Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
349
Cognitive Development During Adulthood01:30

Cognitive Development During Adulthood

1.4K
Cognitive development continues throughout adulthood, undergoing significant shifts across early, middle, and late stages. Individual transition occurs from adolescent idealism to pragmatic and adaptable thinking in early adulthood. During this period, individuals learn to integrate personal beliefs with the recognition that other perspectives are equally valid. Exposure to the complexities of modern society, diverse experiences, and higher education contribute to this adaptive thought process,...
1.4K
Dementia l: Introduction01:22

Dementia l: Introduction

4
Dementia is an acquired, progressive syndrome characterized by a decline in multiple cognitive domains severe enough to impair daily functioning and reduce independence. Although memory loss is a central feature, the diagnosis requires additional deficits involving language, executive function, visuospatial skills, judgment, calculation, or abstract reasoning. These cognitive impairments reflect underlying neurodegenerative or vascular processes that gradually disrupt neuronal networks...
4
Alzheimer's Disease: Overview01:26

Alzheimer's Disease: Overview

2.0K
Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
2.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Development of a Humanized Anti-Fibrotic Antibody Targeting Extracellular Collagen Assembly to Reduce Post-Traumatic Scarring.

bioRxiv : the preprint server for biology·2026
Same author

Simulated Workflow Feasibility Evaluation of a Web-Based Periorbital Measurement Platform: Development and Usability Study.

JMIR human factors·2026
Same author

Alternate splicing converts human CD137 from costimulatory to immunosuppressive function.

Journal of autoimmunity·2025
Same author

Seroprevalence of dengue virus infection among febrile patients visiting healthcare facilities in the selected districts of Afar region, Northeast Ethiopia.

BMC infectious diseases·2025
Same author

Higher order receptor clustering due to the IgG3 subclass is necessary for TLR4 signaling and tolerance induction by novel human anti-TLR4 antibodies.

mAbs·2025
Same author

Neutralization of Marinobufagenin Demonstrates Efficacy In Vitro and In Vivo in Models of Pre-Eclampsia.

Biomedicines·2025

Related Experiment Video

Updated: Apr 20, 2026

Assessment of Age-related Changes in Cognitive Functions Using EmoCogMeter, a Novel Tablet-computer Based Approach
10:13

Assessment of Age-related Changes in Cognitive Functions Using EmoCogMeter, a Novel Tablet-computer Based Approach

Published on: February 14, 2014

14.3K

Systemic factors mediate reversible age-associated brain dysfunction.

Andrew R Mendelsohn1, James W Larrick

  • 1Panorama Research Institute and Regenerative Sciences Institute , Sunnyvale, California.

Rejuvenation Research
|November 18, 2014
PubMed
Summary

Aging brains show declining function due to altered blood factors. Restoring growth/differentiation factor 11 (GDF11) and modulating type I interferon (IFN-I) signaling show potential for brain rejuvenation therapies.

More Related Videos

A Mouse Model of Orthopedic Surgery to Study Postoperative Cognitive Dysfunction and Tissue Regeneration
08:17

A Mouse Model of Orthopedic Surgery to Study Postoperative Cognitive Dysfunction and Tissue Regeneration

Published on: February 27, 2018

17.2K
Abbiategrasso Brain Bank Protocol for Collecting, Processing and Characterizing Aging Brains
12:28

Abbiategrasso Brain Bank Protocol for Collecting, Processing and Characterizing Aging Brains

Published on: June 3, 2020

18.6K

Related Experiment Videos

Last Updated: Apr 20, 2026

Assessment of Age-related Changes in Cognitive Functions Using EmoCogMeter, a Novel Tablet-computer Based Approach
10:13

Assessment of Age-related Changes in Cognitive Functions Using EmoCogMeter, a Novel Tablet-computer Based Approach

Published on: February 14, 2014

14.3K
A Mouse Model of Orthopedic Surgery to Study Postoperative Cognitive Dysfunction and Tissue Regeneration
08:17

A Mouse Model of Orthopedic Surgery to Study Postoperative Cognitive Dysfunction and Tissue Regeneration

Published on: February 27, 2018

17.2K
Abbiategrasso Brain Bank Protocol for Collecting, Processing and Characterizing Aging Brains
12:28

Abbiategrasso Brain Bank Protocol for Collecting, Processing and Characterizing Aging Brains

Published on: June 3, 2020

18.6K

Area of Science:

  • Neuroscience
  • Aging Research
  • Immunology

Background:

  • Brain function deteriorates with age in mammals.
  • Dysregulated blood factors during aging negatively impact cognitive abilities.
  • Key factors include C-C motif chemokine 11 (CCL11), growth/differentiation factor 11 (GDF11), and type I/II interferons (IFN-I/II).

Purpose of the Study:

  • To investigate the roles of GDF11 and interferon signaling in age-related brain dysfunction.
  • To explore potential therapeutic interventions for reversing cognitive decline.
  • To understand the mechanisms linking aging, blood factors, and brain health.

Main Methods:

  • Administered GDF11 to aged mice to assess its effects on brain function and neurogenesis.
  • Analyzed interferon signaling (IFN-I and IFN-II) at the choroid plexus (CP) in aging mice.
  • Injected anti-interferon-α/β receptor (IFNAR) antibodies into cerebrospinal fluid (CSF) to block IFN-I signaling.

Main Results:

  • GDF11 injection partially restored brain function and neurogenesis by improving vasculature.
  • Aging was associated with decreased IFN-II and increased IFN-I signaling at the CP.
  • Blocking IFN-I signaling via anti-IFNAR antibodies reduced CCL11 expression and partially restored neurogenesis and cognitive function.

Conclusions:

  • Aging-associated brain dysfunction involves specific, potentially reversible changes in blood-borne factors and immune signaling.
  • GDF11 and modulation of IFN-I signaling represent promising targets for developing rejuvenative therapies for the aging brain.
  • IFN-I signaling critically drives increased CCL11 expression in the aging brain.