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Profiling of Estrogen-regulated MicroRNAs in Breast Cancer Cells
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Regulation of ERBB3/HER3 signaling in cancer

Kalpana Mujoo1, Byung-Kwon Choi2, Zhao Huang2

  • 1Texas Therapeutics Institute, Brown Foundation Institute of Molecular Medicine, The University of Texas Health Science Center at Houston, Houston, Texas. Current address: Department of Radiation Oncology, Houston Methodist Research Institute, Houston, TX.

Oncotarget
|November 18, 2014
PubMed

Insights

The human epidermal growth factor receptor 3 (HER3) is a key target in cancer therapy, particularly when cancers become resistant to other treatments. Further research into HER3 regulation is crucial for developing effective targeted therapies.

Area of Science:

  • Oncology
  • Molecular Biology
  • Cancer Therapeutics

Background:

  • The human epidermal growth factor receptor 3 (HER3) is increasingly recognized as a significant molecular target in various cancers.
  • HER3 overexpression and activation are observed in cancers that develop acquired resistance to existing HER family-targeted therapies, including tyrosine kinase inhibitors and antibody treatments.

Purpose of the Study:

  • To highlight the critical role of HER3 in cancer development and therapeutic resistance.
  • To emphasize the need for further research into the complex regulation of HER3 expression and signaling.
  • To address the challenge posed by the lack of biomarkers for HER3-driven cancers in the clinical development of HER3-targeting antibodies.

Main Methods:

  • Review of current literature on HER3 function, regulation, and therapeutic targeting.
  • Analysis of HER3 interacting proteins (e.g., PI3K, Shc, NEDD4, Nrdp1) involved in its signaling pathways.
  • Examination of identified HER3 oncogenic mutations in colon and gastric cancers.

Main Results:

  • HER3 plays a crucial role in cancer development, with its oncogenic mutations identified in colon and gastric cancers.
  • Numerous proteins, including PI3K, Shc, NEDD4, and Nrdp1, are involved in regulating HER3 expression and signaling.
  • Acquired resistance to current HER-targeted therapies often involves HER3 overexpression and activation.

Conclusions:

  • A deeper understanding of HER3 regulation is essential for improving therapeutic strategies against HER3-driven cancers.
  • Development of specific biomarkers for HER3-driven cancers is critical for advancing the clinical development of HER3-targeting antibodies.
  • Targeting HER3 holds significant promise for overcoming therapeutic resistance in various cancer types.

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