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Fetal valproate syndrome.
Parmarth G Chandane1, Ira Shah1
1Department of Pediatrics, Bai Jerbai Wadia Hospital for Children, Parel, Mumbai, Maharashtra, India.
Indian Journal of Human Genetics
|November 18, 2014
Summary
Antenatal exposure to valproic acid, an anticonvulsant, can cause fetal valproate syndrome (FVS), characterized by developmental issues and birth defects. Avoiding this medication during pregnancy is crucial for fetal health.
Area of Science:
- Teratology
- Developmental Pediatrics
- Neurology
Background:
- Sodium valproate is a widely prescribed anticonvulsant and mood-stabilizing medication.
- Antenatal exposure to certain medications can pose risks to fetal development.
- Fetal Valproate Syndrome (FVS) is a known consequence of in-utero valproic acid exposure.
Observation:
- A case report details a male infant born with features consistent with FVS.
- The infant's mother, aged 26, had epilepsy controlled with sodium valproate (800 mg/day) for 3 years.
- The mother experienced three spontaneous first-trimester abortions during the same period.
Findings:
- The infant presented with a typical cluster of facial dysmorphism, congenital anomalies, and neurodevelopmental retardation.
- Sodium valproate is identified as a teratogen associated with FVS.
- The teratogenic effects include facial dysmorphism, craniosynostosis, neural tube defects, and neurodevelopmental delays.
Implications:
- Strongly recommend avoiding valproic acid during pregnancy due to its teratogenic potential.
- Highlight the importance of folic acid supplementation for pregnant individuals, especially those on anticonvulsants.
- Emphasize the need for comprehensive counseling regarding medication risks during pregnancy.
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