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Published on: February 2, 2021
Dysregulation of JAM-A plays an important role in human tumor progression
Chen Zhao1, Funian Lu1, Hongxia Chen1
1Department of Pathology, School of Basic Medical Science, Wuhan University Wuhan 430071, P. R. China.
Abstract:
Junctional adhesion molecule A (JAM-A) is a transmembrane protein that belongs to the immunoglobulin (Ig) superfamily. Evidence determines that JAM-A plays a role in numerous cellular processes, including tight junction assembly, leukocyte migration, platelet activation, angiogenesis and virus binding. Recent research suggests that JAM-A is dysregulated in various cancers and is vital for tumor progression. JAM-A is implicated in carcinogenesis via different signal pathways such as TGF-β1 signaling. Furthermore, JAM-A expression in cancers is usually associated with certain outcome of patients and might be a prognostic indicator. In this review, the correlation between JAM-A expression and human cancers will be described.
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