Concomitant angiosarcoma and lymphoproliferative disorder in solid organ transplant recipients

Area of Science:

• Oncology
• Transplantation Medicine
• Pathology

Background:

• Solid organ transplant recipients have an increased risk of developing malignancies.
• Common posttransplant cancers include skin, lung, breast carcinomas, and lymphoproliferative disorders.
• Angiosarcoma is a rare vascular neoplasm, infrequently observed in the posttransplant context.

Purpose of the Study:

• To report two cases of high-grade angiosarcoma occurring after solid organ transplantation.
• To investigate the potential association between angiosarcoma and prior lymphoproliferative disorders in transplant recipients.

Main Methods:

• Case report of two patients with solid organ transplants.
• Review of medical history, including diagnoses and pathological findings.
• Analysis of lymphoproliferative disorder characteristics, specifically immunoglobulin heavy chain rearrangement.

Main Results:

• Two patients developed high-grade angiosarcoma post-solid organ transplant.
• Both patients had a preceding diagnosis of a lymphoproliferative disorder.
• The lymphoproliferative disorder in both cases exhibited monoclonal immunoglobulin heavy chain rearrangement.

Conclusions:

• High-grade angiosarcoma can occur in the posttransplant setting, although rare.
• A preceding lymphoproliferative disorder with monoclonal immunoglobulin heavy chain rearrangement may be associated with the development of angiosarcoma in solid organ transplant recipients.