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Updated: Apr 20, 2026

Synthesis of a Thiol Building Block for the Crystallization of a Semiconducting Gyroidal Metal-sulfur Framework
Published on: April 9, 2018
Solid phase synthesis of functionalised SAM-forming alkanethiol-oligoethyleneglycols
James Murray1, Dominika Nowak2, Laurynas Pukenas3
1School of Chemistry, University of Leeds, LS2 9JT, UK ; Astbury Centre for Structural Molecular Biology, University of Leeds, UK.
We developed a new synthesis method for functionalized long-chain alkanethiol-oligoethyleneglycols. These molecules form self-assembled monolayers on gold, useful for biosensing applications with minimal biofouling.
Area of Science:
- Materials Science
- Organic Chemistry
- Biotechnology
Background:
- Self-assembled monolayers (SAMs) are crucial for surface functionalization.
- Long-chain alkanethiol-oligoethyleneglycols (LCAT-OEGs) offer versatile surface modification properties.
- Efficient synthesis of functionalized LCAT-OEGs is needed for advanced applications.
Purpose of the Study:
- To develop an efficient solid-phase synthesis for functionalized LCAT-OEGs.
- To demonstrate the versatility of the synthesized LCAT-OEGs for conjugation.
- To evaluate the performance of LCAT-OEG monolayers in biosensing.
Main Methods:
- Solid-phase synthesis of LCAT-OEGs with various functional groups.
- Formation of well-defined SAMs on gold surfaces.
- Characterization of SAMs and their conjugation capabilities.
- Application of LCAT-OEG SAMs in an immunosensing platform.
Main Results:
- Successful synthesis of diverse functionalized LCAT-OEGs.
- Formation of stable and well-defined SAMs on gold.
- Demonstrated compatibility with pre- and post-assembly conjugation of biomolecules.
- LCAT-OEG monolayers exhibited good biocompatibility and minimal biofouling in immunosensing.
Conclusions:
- The developed solid-phase synthesis is an efficient route to functionalized LCAT-OEGs.
- LCAT-OEG SAMs are versatile platforms for biomolecule conjugation and biosensing.
- These SAMs offer promising biocompatibility and anti-fouling properties for bio-interfacing.
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