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Hemoglobin variant (hemoglobin Aalborg) mimicking interstitial pulmonary disease
Vasiliki Panou1, Peter-Diedrich Mathias Jensen2, Jan Freddy Pedersen3
1Department of Respiratory Diseases, Aalborg University Hospital, Mølleparkvej 4, 9000 Aalborg, Denmark.
Pulmonary Medicine
|November 18, 2014
Summary
Hemoglobin Aalborg, a variant hemoglobin, can cause respiratory issues, even in healthy individuals, after surgery. Testing relatives revealed consistent physiological abnormalities, suggesting this diagnosis should be considered.
Area of Science:
- Hematology
- Pulmonary Medicine
- Clinical Physiology
Background:
- Hemoglobin Aalborg is a moderately unstable hemoglobin variant typically asymptomatic.
- A 58-year-old woman presented with acute respiratory failure post-cholecystectomy, initially misdiagnosed.
Observation:
- The patient's condition prompted an investigation into relatives with known Hemoglobin Aalborg.
- Physiological tests included spirometry, body plethysmography, 6-minute walking test, pulse oximetry, and arterial blood gas analysis.
Findings:
- A reduced diffusion capacity was observed in all affected individuals.
- Abnormalities in partial pressure of oxygen (P(a)O2) and p50 values were noted.
- Pulse oximetry and arterial blood gas saturation measurements showed concordance.
Implications:
- These physiological anomalies suggest Hemoglobin Aalborg should be considered in diagnosing respiratory complications.
- Early identification of Hemoglobin Aalborg can prevent misdiagnosis and guide appropriate management.
- Further research into the clinical manifestations and management of Hemoglobin Aalborg is warranted.
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