Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Caprine arthritis encephalitis--a model for AIDS?

O C Straub1

  • 1Bundesforschungsanstalt für Viruskrankheiten der Tiere, Tübingen, BRD.

Intervirology
|January 1, 1989
PubMed
Summary

Caprine arthritis encephalitis (CAE) virus, related to Maedi/Visna virus and HIV, offers insights into lentiviral infections. CAE serves as a valuable nonprimate model for HIV research, aiding in evaluating treatments and vaccines.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Advances in BHV1 (IBR) research.

DTW. Deutsche tierarztliche Wochenschrift·2001
Same author

Bovine immunodeficiency virus and analogies with human immunodeficiency virus.

Leukemia·1999
Same author

Analysis of the phenotype and phagocytic activity of monocytes/macrophages from cattle infected with the bovine leukaemia virus.

Veterinary immunology and immunopathology·1998
Same author

Risk of BSE from the import of cattle from the United Kingdom into countries of the European Union.

The Veterinary record·1997
Same author

BSE: a European problem.

The Veterinary record·1996
Same author

Detection of scrapie agent in the peripheral nervous system of a diseased sheep.

Neurobiology of disease·1996

Area of Science:

  • Veterinary Virology
  • Retroviral Research
  • Comparative Medicine

Background:

  • The subfamily Lentivirinae includes viruses with significant impact on animal and human health.
  • Maedi/Visna virus (MVV) and caprine arthritis encephalitis virus (CAEV) share characteristics with human immunodeficiency virus (HIV).
  • Understanding lentiviral pathogenesis is crucial for developing effective interventions.

Purpose of the Study:

  • To provide a comprehensive overview of current knowledge on CAEV.
  • To explore the potential of CAEV as a nonprimate model in HIV research.
  • To highlight CAEV's utility in evaluating therapeutic compounds, vaccines, and immunostimulants for HIV.

Main Methods:

  • Literature review of CAEV's clinical presentation, pathology, and epidemiology.
  • Comparative analysis of lentiviral genetic and biological features.
  • Exploration of CAEV's suitability as a model system for HIV studies.

Main Results:

  • CAEV exhibits distinct clinical signs and pathological lesions in goats.
  • Global distribution and transmission routes of CAEV are documented.
  • CAEV shares biological similarities with HIV, making it a relevant model.

Conclusions:

  • CAEV is an important caprine lentivirus with significant economic impact.
  • CAEV presents a viable nonprimate model for advancing HIV research.
  • Further studies using CAEV can accelerate the development of HIV therapies and vaccines.

Related Experiment Videos