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An improved HPLC system for the analysis and purification of organic amine radiopharmaceuticals
M J Adam1, J R Grierson, S Jivan
1UBC/TRIUMF Program on Positron Emission Tomography, Vancouver, Canada.
International Journal of Radiation Applications and Instrumentation. Part A, Applied Radiation and Isotopes
|January 1, 1989
Abstract:
This paper describes the separation of lipophilic amine radiopharmaceuticals on normal phase silica using a reversed phase type eluant. This class of compound usually gives very poor peak symmetry on reversed phase columns. However, excellent separation of a number of amines of interest to Positron Emission Tomography, such as spiperone and its derivatives, has been achieved on this system.