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Updated: Apr 20, 2026
Assessment of Maternal Vascular Remodeling During Pregnancy in the Mouse Uterus
Published on: December 5, 2015
Maternal thrombophilia and adverse pregnancy outcome: a case-control study
Maria Gabriella Mazzucconi1, Vitaliana De Sanctis, Marco Alfò
1Department of Cellular Biotechnology and Hematology, University 'Sapienza', Rome, Italy.
Objective:
To assess the risk of adverse pregnancy outcomes in patients with acquired and/or congenital thrombophilia factors.
Patients And Methods:
A cohort of 130 women with a history of pregnancy loss and no successful gestation were investigated for the presence of congenital and acquired thrombophilia factors, and then compared with a control group of 130 healthy women who had had at least one successful gestation and no pregnancy loss, and were screened for congenital and acquired thrombophilia factors.
Results:
Acquired and congenital thrombophilia factors were found in 30 (23%) patients and in 14 (10.8%) controls (p < 0.015). The presence of ≥1 congenital thrombophilia factor was associated with pregnancy loss with an odds ratio of 2.46 (p = 0.040). Moreover, women who had had >1 early fetal loss had a 2.85-fold risk of being carriers of congenital thrombophilia factors, compared to the controls.
Conclusion:
Our study showed the increased risk of miscarriage in patients with congenital thrombophilia factors and >1 early fetal loss.
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