Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Factors Affecting Renal Clearance: Renal Impairment01:17

Factors Affecting Renal Clearance: Renal Impairment

569
Renal dysfunction significantly impairs the renal clearance of drugs, leading to potential complications in drug therapy. Renal failure, which can be caused by various factors, poses a significant challenge in the elimination of drugs from the body.
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...
569
Drug Dosing in Renal Diseases: Measurement of Serum Creatinine Concentration and Clearance01:25

Drug Dosing in Renal Diseases: Measurement of Serum Creatinine Concentration and Clearance

361
In healthy individuals, serum creatinine levels remain stable due to a balance between its constant production—primarily from muscle metabolism—and renal excretion. Creatinine is freely filtered by the glomeruli, making it a valuable marker for estimating renal function. When the glomerular filtration rate (GFR) decreases, the kidneys can only eliminate less creatinine, causing serum levels to rise.Serum creatinine concentration is widely used to estimate creatinine clearance...
361
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion01:18

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion

336
In geriatric patients, renal physiology undergoes significant changes, including diminished renal blood flow and a lower glomerular filtration rate (GFR), leading to alterations in medication clearance. Drugs such as aminoglycoside antibiotics, lithium, and digoxin, which rely on glomerular filtration for removal from the body, particularly impact pharmacokinetics. These drugs tend to have slower clearance rates in older adults, necessitating careful dosage considerations.Evaluation of renal...
336
Chronic Kidney Disease I: Introduction01:25

Chronic Kidney Disease I: Introduction

1.3K
Chronic Kidney Disease (CKD) arises when the kidneys progressively lose their ability to function, ultimately leading to end-stage renal disease. At this advanced stage, the kidneys can no longer filter waste or maintain essential body functions, requiring renal replacement therapy (RRT) through dialysis or a kidney transplant for survival.Early-stage chronic kidney disease and detection challengesIn CKD's early stages, symptoms often remain absent because healthy nephrons compensate for...
1.3K
Drug Dosing in Renal Diseases: Estimation of Glomerular Filtration Rate Based on Serum Creatinine Concentration01:28

Drug Dosing in Renal Diseases: Estimation of Glomerular Filtration Rate Based on Serum Creatinine Concentration

327
Glomerular filtration rate (GFR) can be estimated from serum creatinine using the modification of diet in renal disease (MDRD) formula or the chronic kidney disease–epidemiology collaboration (CKD–EPI) equation. Both methods are widely used in clinical practice to assess kidney function and guide treatment decisions.The MDRD equation does not require weight or height measurements and is normalized to the body surface area of 1.73 m², considered the average adult surface area.
327
Renal Clearance01:23

Renal Clearance

3.4K
The glomerular filtration rate (GFR) is a critical marker of kidney function, reflecting the efficiency of filtration by the glomeruli. Renal clearance of specific substances, such as inulin or creatinine, is commonly used to measure GFR.
Renal clearance refers to the volume of plasma cleared of a specific substance, such as creatinine, per unit of time. To measure clearance, urine samples are collected over a 24-hour period during each bladder voiding, followed by a single blood sample at the...
3.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A three-year randomized, double-blind, placebo-controlled study of lanreotide in stage 2/3 autosomal dominant polycystic kidney disease.

Kidney international·2026
Same author

French nephrologists’ practices in the management of anemia and iron deficiency in chronic kidney disease

Nephrologie & therapeutique·2026
Same author

Copeptin is a reliable biomarker of vasopressin and is associated with urine osmolality in patients on peritoneal dialysis.

Journal of nephrology·2026
Same author

Optimal patient care in advanced chronic kidney disease progressing to kidney failure.

Nature reviews. Nephrology·2026
Same author

Health-related quality of life in nondialysis CKD patients: a comprehensive description of five-year trajectories among the CKD-REIN cohort.

BMC nephrology·2026
Same author

Furosemide and the Symptom Burden: The Potential Mediating Role of Uremic Toxins in Patients with CKD.

Toxins·2025
Same journal

Invaders taking over-Mollusc faunal change in volcanic barrier lakes of the Albertine Rift biodiversity hotspot.

PloS one·2026
Same journal

AI-driven molecular diversification and ligand-based optimization of macitentan derivatives targeting VEGFR1 and endothelin signaling pathways.

PloS one·2026
Same journal

Performance patterns and records in the world aquatics masters championships: Where do the most frequently represented nations among the top-ten masters swimmers come from?

PloS one·2026
Same journal

Modeling diurnal Temperature-Rainfall relationships under multicollinearity using PLS-SEM: A case study of Ghana.

PloS one·2026
Same journal

Organizational culture, social capital, and emergency capacity in primary healthcare institutions: A cross-sectional structural equation modeling study comparing ordinary and older communities.

PloS one·2026
Same journal

Impact of kidney function on the metabolome in the general population.

PloS one·2026
See all related articles

Related Experiment Video

Updated: Apr 20, 2026

Ischemia-reperfusion Model of Acute Kidney Injury and Post Injury Fibrosis in Mice
09:09

Ischemia-reperfusion Model of Acute Kidney Injury and Post Injury Fibrosis in Mice

Published on: August 9, 2013

41.2K

Decrease in urinary creatinine excretion in early stage chronic kidney disease.

Elena Tynkevich1, Martin Flamant2, Jean-Philippe Haymann3

  • 1CESP, Centre for Epidemiology and Population Health, INSERM Unit 1018, Villejuif, France; University Paris-Sud 11, UMRS 1018, Villejuif, France.

Plos One
|November 18, 2014
PubMed
Summary
This summary is machine-generated.

Muscle mass loss can occur early in chronic kidney disease (CKD). Reduced kidney function significantly lowers urinary creatinine excretion, indicating muscle loss is linked to CKD progression.

More Related Videos

A High-throughput Method for Measurement of Glomerular Filtration Rate in Conscious Mice
07:07

A High-throughput Method for Measurement of Glomerular Filtration Rate in Conscious Mice

Published on: May 10, 2013

44.5K
5/6 Nephrectomy Using Sharp Bipolectomy Via Midline Laparotomy in Rats
05:34

5/6 Nephrectomy Using Sharp Bipolectomy Via Midline Laparotomy in Rats

Published on: April 4, 2025

2.0K

Related Experiment Videos

Last Updated: Apr 20, 2026

Ischemia-reperfusion Model of Acute Kidney Injury and Post Injury Fibrosis in Mice
09:09

Ischemia-reperfusion Model of Acute Kidney Injury and Post Injury Fibrosis in Mice

Published on: August 9, 2013

41.2K
A High-throughput Method for Measurement of Glomerular Filtration Rate in Conscious Mice
07:07

A High-throughput Method for Measurement of Glomerular Filtration Rate in Conscious Mice

Published on: May 10, 2013

44.5K
5/6 Nephrectomy Using Sharp Bipolectomy Via Midline Laparotomy in Rats
05:34

5/6 Nephrectomy Using Sharp Bipolectomy Via Midline Laparotomy in Rats

Published on: April 4, 2025

2.0K

Area of Science:

  • Nephrology
  • Muscle Metabolism
  • Biochemistry

Background:

  • Muscle mass loss is poorly understood in early chronic kidney disease (CKD).
  • 24-hour urinary creatinine excretion rate is a key indicator of muscle mass.
  • Understanding muscle mass changes is crucial for managing CKD progression.

Purpose of the Study:

  • To assess the determinants of muscle mass in CKD patients.
  • To evaluate how muscle mass changes with declining kidney function.
  • To describe urinary creatinine concentration ranges in CKD patients.

Main Methods:

  • Included 1072 men and 537 women with non-dialysis CKD stages 1-5.
  • Measured glomerular filtration rate (mGFR) using (51)Cr-EDTA renal clearance.
  • Utilized mixed models to analyze factors associated with urinary creatinine excretion rate and its changes over time.

Main Results:

  • Urinary creatinine excretion decreased significantly with declining mGFR in both men and women.
  • Older age, diabetes, lower BMI, proteinuria, and protein intake were associated with lower creatinine excretion.
  • Rapid mGFR decline led to a more than twofold increase in urinary creatinine excretion reduction, independent of protein intake.

Conclusions:

  • Urinary creatinine excretion reduction is an early marker in CKD, worsening with greater mGFR decline.
  • This decrease is independent of reduced protein intake.
  • Normalizing urine analytes for creatininuria may overestimate concentrations in CKD patients with low muscle mass.