Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Vaccinations01:51

Vaccinations

54.7K
Overview
54.7K
Vaccines01:21

Vaccines

63
Vaccines are among the most effective tools in preventive medicine, designed to prepare the immune system to recognize and combat infectious agents. By introducing antigens—substances that the immune system identifies as foreign—vaccines stimulate an adaptive immune response that leads to immunological memory. This immunological memory enables the body to mount a faster and more effective response upon future exposures to the actual pathogen.Vaccines can be categorized based on the...
63
Pharmacodynamics in Geriatric Patients: Effects of Age01:27

Pharmacodynamics in Geriatric Patients: Effects of Age

349
Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
349
Cancer Vaccines01:30

Cancer Vaccines

1.4K
Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
1.4K
Drug Dosing: Geriatric Patients01:15

Drug Dosing: Geriatric Patients

376
Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
376
Aging01:26

Aging

1.1K
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
1.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Influenza vaccine-specific CD4<sup>+</sup> T cell responses are impaired in older adults.

NPJ vaccines·2026
Same author

Biologically Younger Individuals, as Identified by MARK-AGE Biological Age Scores, Display a Distinct Favourable Blood Chemistry Profile Regardless of Age.

Aging cell·2026
Same author

Phenotypic and functional heterogeneity of naïve CD8<sup>+</sup> T cells in human peripheral blood during aging.

Frontiers in aging·2026
Same author

TTV Species Diversity as a Novel Biomarker of Immune Dysregulation in Aging.

Journal of medical virology·2025
Same author

[Age-associated changes of the immune system: immunosenescence and effects on vaccinations].

Zeitschrift fur Gerontologie und Geriatrie·2025
Same author

Causal Inference Approaches Reveal Associations Between LDL Oxidation, NO Metabolism, Telomere Length and DNA Integrity Within the MARK-AGE Study.

Antioxidants (Basel, Switzerland)·2025

Related Experiment Video

Updated: Apr 20, 2026

Fabrication of Pulsatile Polymeric Microparticles Encapsulating Rabies Antigen
07:44

Fabrication of Pulsatile Polymeric Microparticles Encapsulating Rabies Antigen

Published on: May 12, 2023

1.8K

Vaccines for the elderly.

Giuseppe Del Giudice1, Birgit Weinberger, Beatrix Grubeck-Loebenstein

  • 1Novartis Vaccines, Research Center, Siena, Italy.

Gerontology
|November 18, 2014
PubMed
Summary

Aging populations face increased infectious disease risks. A holistic approach, including better vaccine use and development, is crucial for elderly health and immunity.

Area of Science:

  • Gerontology
  • Immunology
  • Public Health

Background:

  • The global human population is aging, presenting significant challenges for disease prevention in the elderly.
  • While vaccines for influenza, pneumococci, and others exist for seniors, further adaptation and new vaccine development are needed.
  • Infectious diseases disproportionately affect the elderly, necessitating improved preventative strategies.

Purpose of the Study:

  • To outline a holistic approach for preventing infectious diseases in the aging population.
  • To emphasize the need for a deeper understanding of immune system senescence.
  • To advocate for optimized vaccine strategies in the elderly.

Main Methods:

  • Reviewing current vaccination practices for the elderly.

More Related Videos

Synthesis and Characterization of mRNA-Loaded PolyBeta Aminoesters Nanoparticles for Vaccination Purposes
08:27

Synthesis and Characterization of mRNA-Loaded PolyBeta Aminoesters Nanoparticles for Vaccination Purposes

Published on: August 13, 2021

5.3K
Enrichment of Native and Recombinant Extracellular Vesicles of Mycobacteria
06:38

Enrichment of Native and Recombinant Extracellular Vesicles of Mycobacteria

Published on: December 8, 2023

1.8K

Related Experiment Videos

Last Updated: Apr 20, 2026

Fabrication of Pulsatile Polymeric Microparticles Encapsulating Rabies Antigen
07:44

Fabrication of Pulsatile Polymeric Microparticles Encapsulating Rabies Antigen

Published on: May 12, 2023

1.8K
Synthesis and Characterization of mRNA-Loaded PolyBeta Aminoesters Nanoparticles for Vaccination Purposes
08:27

Synthesis and Characterization of mRNA-Loaded PolyBeta Aminoesters Nanoparticles for Vaccination Purposes

Published on: August 13, 2021

5.3K
Enrichment of Native and Recombinant Extracellular Vesicles of Mycobacteria
06:38

Enrichment of Native and Recombinant Extracellular Vesicles of Mycobacteria

Published on: December 8, 2023

1.8K
  • Identifying knowledge gaps in immune senescence.
  • Proposing strategies for broader vaccine application and early immunization.

    • Main Results:

    • Current vaccination strategies for the elderly require enhancement.
    • Understanding immune system aging is key to improving vaccine efficacy.
    • A multi-faceted approach is necessary for effective infectious disease prevention in seniors.

    Conclusions:

    • A comprehensive strategy involving enhanced vaccine use, new vaccine development, and early immune priming is essential.
    • Addressing immune senescence is critical for successful vaccination outcomes in the elderly.
    • Proactive public health measures are required to protect the aging population from infectious diseases.