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Dermorphin inhibits micturition reflex in rats at a central site of action
C A Maggi1, S Giuliani, A Meli
1Pharmacology Department, A. Menarini Pharmaceuticals, Florence, Italy.
Journal of the Autonomic Nervous System
|February 1, 1989
Abstract:
Intrathecal dermorphin (0.8-80 ng) or [D-Ala2, D-Leu5]-enkephalin (DADLE, 5.7-171 ng) produced a dose-related marked inhibition of reflex micturition in urethane-anesthetized rats until voiding was suppressed and overflow incontinence ensued. These effects of dermorphin or DADLE were promptly abolished by i.v. naloxone (0.2 mg/kg). The inhibitory effect of dermorphin but not that of DADLE was partially prevented by systemic capsaicin desensitization (50 mg/kg s.c., 4 days before). Intravenous dermorphin had little or no effect on micturition up to 8 micrograms/kg.