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Anticancer agents from marine sponges.

Jianjun Ye1, Feng Zhou, Ammar M Q Al-Kareef

  • 1a College of Pharmaceutical Science, Zhejiang University of Technology , Hangzhou 310014 , China.

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|November 18, 2014
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Marine sponges yield numerous anticancer compounds. This review covers novel sponge metabolites discovered in the last five years that show significant anticancer activity against various cancer types.

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Area of Science:

  • Marine Biology
  • Natural Product Chemistry
  • Pharmacology

Background:

  • Marine sponges are prolific sources of diverse bioactive metabolites.
  • Over 5300 known metabolites originate from sponges and their associated microbes.
  • Sponges produce secondary metabolites, including anticancer agents, as a defense mechanism.

Purpose of the Study:

  • To review novel secondary metabolites from marine sponges with anticancer activity.
  • To highlight compounds discovered within the last five years.
  • To categorize these natural products based on chemical characteristics.

Main Methods:

  • Literature review of scientific publications from the past five years.
  • Identification and selection of studies reporting novel sponge-derived metabolites with anticancer properties.
  • Classification of metabolites based on their chemical structures.

Main Results:

  • Identification of numerous novel secondary metabolites from marine sponges.
  • Demonstration of significant anticancer activity of these compounds against various cancer cell lines.
  • Categorization of these anticancer agents based on chemical classes.

Conclusions:

  • Marine sponges continue to be a vital source of novel anticancer drug leads.
  • Recent discoveries underscore the potential of sponge-derived natural products in cancer therapy.
  • Further research into sponge metabolites could yield new therapeutic strategies for cancer treatment.